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Gene: MUC5AC (mucin 5AC, oligomeric mucus/gel-forming) Homo sapiens
Symbol: MUC5AC
Name: mucin 5AC, oligomeric mucus/gel-forming
Description: Predicted to have extracellular matrix structural constituent. Involved in phosphatidylinositol-mediated signaling. Localizes to the cytoplasm; extracellular space; and mucus layer. Implicated in dry eye syndrome. Biomarker of several diseases, including Sjogren's syndrome; biliary tract disease (multiple); cystic fibrosis; eye disease (multiple); and pancreatic cancer (multiple); INTERACTS WITH (R)-mevalonic acid; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: gastric mucin; leB; lewis B blood group antigen; major airway glycoprotein; MUC-5AC; MUC5; mucin; mucin 5, subtypes a and c; mucin 5, subtypes A and C, tracheobronchial/gastric; mucin 5AC, oligomeric mucus/gel-forming pseudogene; mucin-5 subtype AC, tracheobronchial; mucin-5AC; TBM; tracheobronchial mucin
Mus musculus (house mouse) : Muc5ac (mucin 5, subtypes A and C, tracheobronchial/gastric)  MGI  Alliance
Rattus norvegicus (Norway rat) : Muc5ac (mucin 5AC, oligomeric mucus/gel-forming)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Muc5ac (mucin 5AC, oligomeric mucus/gel-forming)
Pan paniscus (bonobo/pygmy chimpanzee) : MUC5AC (mucin 5AC, oligomeric mucus/gel-forming)
Canis lupus familiaris (dog) : MUC5AC (mucin 5AC, oligomeric mucus/gel-forming)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Muc5ac (mucin 5AC, oligomeric mucus/gel-forming)
Sus scrofa (pig) : MUC5AC (mucin 5AC, oligomeric mucus/gel-forming)
Chlorocebus sabaeus (African green monkey) : MUC5AC (mucin 5AC, oligomeric mucus/gel-forming)
Heterocephalus glaber (naked mole-rat) : Muc5ac (mucin 5AC, oligomeric mucus/gel-forming)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Annotation category: suggests misassembly
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl111,157,953 - 1,201,138 (+)Ensembl
GRCh38111,157,953 - 1,201,138 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37111,142,474 - 1,162,465 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,169,363 - 1,178,940 (+)NCBINCBI36hg18NCBI36
Build 34111,141,594 - 1,152,361NCBI
Celera111,216,270 - 1,325,135 (+)NCBI
Cytogenetic Map11p15.5NCBI
HuRef11979,261 - 1,006,024 (+)NCBIHuRef
CHM1_1111,150,471 - 1,221,279 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on MUC5AC
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737024
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-01-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.