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Gene: CD44 (CD44 molecule (Indian blood group)) Homo sapiens
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Symbol: CD44
Name: CD44 molecule (Indian blood group)
Description: Exhibits hyaluronic acid binding activity. Contributes to cytokine receptor activity. Involved in several processes, including negative regulation of signal transduction by p53 class mediator; positive regulation of cell-cell adhesion; and positive regulation of phosphorylation. Localizes to several cellular components, including the apical plasma membrane; lamellipodium membrane; and macrophage migration inhibitory factor receptor complex. Implicated in breast carcinoma (multiple); carcinoma (multiple); cholestasis; and prostate cancer. Biomarker of Krukenberg carcinoma; invasive ductal carcinoma; leiomyomatosis; lung adenocarcinoma; and urinary system cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD44 antigen; CDW44; cell surface glycoprotein CD44; chondroitin sulfate proteoglycan 8; CSPG8; ECMR-III; epican; extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; HCELL; hematopoietic cell E- and L-selectin ligand; heparan sulfate proteoglycan; Hermes antigen; homing function and Indian blood group system; HUTCH-I; hyaluronate receptor; IN; Indian blood group antigen; LHR; MC56; MDU2; MDU3; MGC10468; MIC4; MUTCH-I; Pgp1; phagocytic glycoprotein 1; soluble CD44
Orthologs:
Mus musculus (house mouse) : Cd44 (CD44 antigen)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cd44 (CD44 molecule (Indian blood group))  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cd44 (CD44 molecule (Indian blood group))
Pan paniscus (bonobo/pygmy chimpanzee) : CD44 (CD44 molecule (Indian blood group))
Canis lupus familiaris (dog) : CD44 (CD44 molecule)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cd44 (CD44 molecule (Indian blood group))
Sus scrofa (pig) : CD44 (CD44 molecule (Indian blood group))
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381135,139,168 - 35,232,402 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371135,160,417 - 35,253,949 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361135,116,993 - 35,210,525 (+)NCBINCBI36hg18NCBI36
Build 341135,116,992 - 35,210,524NCBI
Celera1135,307,730 - 35,401,272 (+)NCBI
Cytogenetic Map11p13NCBI
HuRef1134,858,894 - 34,952,423 (+)NCBIHuRef
CHM1_11135,158,655 - 35,252,358 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on CD44
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737036
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-10-29
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.