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Gene: KPNB1 (karyopherin subunit beta 1) Homo sapiens
Symbol: KPNB1
Name: karyopherin subunit beta 1
Description: Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: IMB1; Impnb; importin 1; importin 90; importin beta-1 subunit; importin subunit beta-1; importin-90; IPO1; IPOB; karyopherin (importin) beta 1; karyopherin subunit beta-1; MGC2155; MGC2156; MGC2157; NTF97; nuclear factor p97; pore targeting complex 97 kDa subunit; PTAC97
Mus musculus (house mouse) : Kpnb1 (karyopherin (importin) beta 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Kpnb1 (karyopherin subunit beta 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kpnb1 (karyopherin subunit beta 1)
Pan paniscus (bonobo/pygmy chimpanzee) : KPNB1 (karyopherin subunit beta 1)
Canis lupus familiaris (dog) : KPNB1 (karyopherin subunit beta 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kpnb1 (karyopherin subunit beta 1)
Sus scrofa (pig) : KPNB1 (karyopherin subunit beta 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381747,649,838 - 47,683,638 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371745,726,861 - 45,762,037 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361743,082,274 - 43,116,003 (+)NCBINCBI36hg18NCBI36
Build 341743,082,273 - 43,116,003NCBI
Celera1742,179,952 - 42,213,682 (+)NCBI
Cytogenetic Map17q21.32NCBI
HuRef1741,096,264 - 41,130,080 (+)NCBIHuRef
CHM1_11745,792,168 - 45,825,949 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on KPNB1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737037
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-06-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.