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Gene: CDKN2A (cyclin dependent kinase inhibitor 2A) Homo sapiens
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Symbol: CDKN2A
Name: cyclin dependent kinase inhibitor 2A
Description: Exhibits several functions, including MDM2/MDM4 family protein binding activity; NF-kappaB binding activity; and enzyme inhibitor activity. Involved in several processes, including regulation of cellular protein localization; regulation of cellular protein metabolic process; and regulation of nucleobase-containing compound metabolic process. Localizes to several cellular components, including mitochondrion; nuclear lumen; and senescence-associated heterochromatin focus. Colocalizes with nuclear body. Implicated in several diseases, including breast cancer (multiple); hematologic cancer (multiple); melanoma (multiple); nervous system cancer (multiple); and pancreatic cancer (multiple). Biomarker of several diseases, including hepatobiliary system cancer (multiple); in situ carcinoma (multiple); leukemia (multiple); reproductive organ cancer (multiple); and urinary system cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: alternative reading frame; ARF; CDK4 inhibitor p16-INK4; CDK4I; CDKN2; cell cycle negative regulator beta; CMM2; cyclin-dependent kinase 4 inhibitor A; cyclin-dependent kinase inhibitor 2A; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2A, isoform 4; cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3; cyclin-dependent kinase inhibitor p16; INK4; INK4a; MLM; MTS-1; MTS1; multiple tumor suppressor 1; P14; p14ARF; P16; p16-INK4; P16-INK4A; p16INK4; p16INK4a; P19; p19Arf; TP16
Orthologs:
Mus musculus (house mouse) : Cdkn2a (cyclin dependent kinase inhibitor 2A)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cdkn2a (cyclin-dependent kinase inhibitor 2A)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : CDKN2A (cyclin dependent kinase inhibitor 2A)
Sus scrofa (pig) : P14ARF (p14ARF protein)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl921,967,753 - 21,995,301 (-)EnsemblGRCh38hg38GRCh38
GRCh38921,967,752 - 21,995,324 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37921,967,751 - 21,994,490 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36921,957,751 - 21,984,490 (-)NCBINCBI36hg18NCBI36
Build 34921,957,751 - 21,984,490NCBI
Celera921,906,103 - 21,932,858 (-)NCBI
Cytogenetic Map9p21.3NCBI
HuRef921,930,969 - 21,957,759 (-)NCBIHuRef
CHM1_1921,967,646 - 21,994,319 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model