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Gene: PRKCA (protein kinase C alpha) Homo sapiens
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Symbol: PRKCA
Name: protein kinase C alpha
Description: Exhibits enzyme binding activity and histone kinase activity (H3-T6 specific). Involved in several processes, including desmosome assembly; histone H3-T6 phosphorylation; and positive regulation of lipopolysaccharide-mediated signaling pathway. Localizes to the cytosol; endoplasmic reticulum; and plasma membrane. Implicated in dilated cardiomyopathy; large cell carcinoma; malignant glioma (multiple); and reproductive organ cancer (multiple). Biomarker of ductal carcinoma in situ; endometrial carcinoma; ovarian carcinoma; and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AAG6; aging-associated gene 6; MGC129900; MGC129901; PKC-A; PKC-alpha; PKCA; PKCalpha; PKCI+/-; PRKACA; protein kinase C alpha type
Orthologs:
Mus musculus (house mouse) : Prkca (protein kinase C, alpha)  MGI  Alliance
Rattus norvegicus (Norway rat) : Prkca (protein kinase C, alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prkca (protein kinase C alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : PRKCA (protein kinase C alpha)
Canis lupus familiaris (dog) : PRKCA (protein kinase C alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prkca (protein kinase C alpha)
Sus scrofa (pig) : PRKCA (protein kinase C alpha)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381766,302,613 - 66,810,743 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371764,298,760 - 64,806,862 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361761,729,388 - 62,237,324 (+)NCBINCBI36hg18NCBI36
Build 341761,729,387 - 62,237,324NCBI
Celera1760,870,958 - 61,379,534 (+)NCBI
Cytogenetic Map17q24.2NCBI
HuRef1759,689,927 - 60,196,110 (+)NCBIHuRef
CHM1_11764,362,982 - 64,870,449 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PRKCA
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737062
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.