Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: PRKCA (protein kinase C alpha) Homo sapiens
Symbol: PRKCA
Name: protein kinase C alpha
Description: Exhibits enzyme binding activity and histone kinase activity (H3-T6 specific). Involved in several processes, including desmosome assembly; histone H3-T6 phosphorylation; and positive regulation of lipopolysaccharide-mediated signaling pathway. Localizes to the cytosol; endoplasmic reticulum; and plasma membrane. Implicated in dilated cardiomyopathy; large cell carcinoma; malignant glioma (multiple); and reproductive organ cancer (multiple). Biomarker of ductal carcinoma in situ; endometrial carcinoma; ovarian carcinoma; and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AAG6; aging-associated gene 6; MGC129900; MGC129901; PKC-A; PKC-alpha; PKCA; PKCalpha; PKCI+/-; PRKACA; protein kinase C alpha type
Mus musculus (house mouse) : Prkca (protein kinase C, alpha)  MGI  Alliance
Rattus norvegicus (Norway rat) : Prkca (protein kinase C, alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prkca (protein kinase C alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : PRKCA (protein kinase C alpha)
Canis lupus familiaris (dog) : PRKCA (protein kinase C alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prkca (protein kinase C alpha)
Sus scrofa (pig) : PRKCA (protein kinase C alpha)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381766,302,613 - 66,810,743 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371764,298,760 - 64,806,862 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361761,729,388 - 62,237,324 (+)NCBINCBI36hg18NCBI36
Build 341761,729,387 - 62,237,324NCBI
Celera1760,870,958 - 61,379,534 (+)NCBI
Cytogenetic Map17q24.2NCBI
HuRef1759,689,927 - 60,196,110 (+)NCBIHuRef
CHM1_11764,362,982 - 64,870,449 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PRKCA
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737062
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.