Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Prkca (protein kinase C, alpha) Mus musculus
Symbol: Prkca
Name: protein kinase C, alpha
Description: Exhibits calcium-dependent protein kinase C activity and integrin binding activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of transmembrane transport; and regulation of protein phosphorylation. Localizes to several cellular components, including the alphav-beta3 integrin-PKCalpha complex; calyx of Held; and presynaptic cytosol. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; large cell carcinoma; malignant glioma (multiple); and reproductive organ cancer (multiple). Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and sensory organ. Orthologous to human PRKCA (protein kinase C alpha); PARTICIPATES IN eicosanoid signaling pathway; endothelin signaling pathway; Fc epsilon receptor mediated signaling pathway; INTERACTS WITH (5Z,8Z,11Z,13E)-15-HETE; (9R)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20-dione; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI875142; expressed sequence AI875142; PKC-A; PKC-alpha; Pkca; protein kinase C alpha type; protein kinase c-alpha
Homo sapiens (human) : PRKCA (protein kinase C alpha)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Prkca (protein kinase C, alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prkca (protein kinase C alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : PRKCA (protein kinase C alpha)
Canis lupus familiaris (dog) : PRKCA (protein kinase C alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prkca (protein kinase C alpha)
Sus scrofa (pig) : PRKCA (protein kinase C alpha)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl11107,933,387 - 108,343,928 (-)Ensembl
GRCm3811107,933,387 - 108,343,888 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3711107,794,701 - 108,205,202 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611107,754,338 - 108,160,018 (-)NCBImm8
Celera11119,670,475 - 120,082,817 (-)NCBICelera
Cytogenetic Map11 E1NCBI
cM Map1170.8NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Prkca
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737063
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-01-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.