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Gene: HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1) Homo sapiens
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Symbol: HSD11B1
Name: hydroxysteroid 11-beta dehydrogenase 1
Description: Predicted to have 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity and steroid binding activity. Predicted to be involved in glucocorticoid biosynthetic process. Localizes to the membrane. Implicated in cortisone reductase deficiency and cortisone reductase deficiency 2. Biomarker of obesity.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 11-beta-HSD1; 11-beta-hydroxysteroid dehydrogenase 1; 11-DH; corticosteroid 11-beta-dehydrogenase isozyme 1; CORTRD2; HDL; HSD11; HSD11B; HSD11L; hydroxysteroid (11-beta) dehydrogenase 1; MGC13539; SDR26C1; short chain dehydrogenase/reductase family 26C member 1; short chain dehydrogenase/reductase family 26C, member 1
Orthologs:
Mus musculus (house mouse) : Hsd11b1 (hydroxysteroid 11-beta dehydrogenase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hsd11b1 (hydroxysteroid 11-beta dehydrogenase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hsd11b1 (hydroxysteroid 11-beta dehydrogenase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1)
Canis lupus familiaris (dog) : HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hsd11b1 (hydroxysteroid 11-beta dehydrogenase 1)
Sus scrofa (pig) : HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1209,686,178 - 209,734,949 (+)Ensembl
GRCh381209,686,180 - 209,734,950 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371209,859,525 - 209,908,295 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361207,926,173 - 207,974,918 (+)NCBINCBI36hg18NCBI36
Build 341206,266,585 - 206,296,690NCBI
Celera1183,090,437 - 183,139,187 (+)NCBI
Cytogenetic Map1q32.2NCBI
HuRef1180,534,794 - 180,583,575 (+)NCBIHuRef
CHM1_11211,131,921 - 211,180,673 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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Molecular Pathway Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on HSD11B1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737091
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-01-14
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.