Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: COMT (catechol-O-methyltransferase) Homo sapiens
Analyze
Symbol: COMT
Name: catechol-O-methyltransferase
CRRD ID: 737102
Description: Exhibits catechol O-methyltransferase activity. Involved in catecholamine catabolic process and methylation. Localizes to cytosol and intracellular membrane-bounded organelle. Implicated in several diseases, including attention deficit hyperactivity disorder; autoimmune disease (multiple); bulimia nervosa; cognitive disorder (multiple); and reproductive organ cancer (multiple). Biomarker of breast cancer; leiomyoma; ovarian cancer; polycystic ovary syndrome; and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: catechol O-methyltransferase; catechol-O-methyltransferase isoform; epididymis secretory sperm binding protein Li 98n; HEL-S-98n; testicular tissue protein Li 42
Orthologs:
Mus musculus (house mouse) : Comt (catechol-O-methyltransferase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Comt (catechol-O-methyltransferase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Comt (catechol-O-methyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : COMT (catechol-O-methyltransferase)
Canis lupus familiaris (dog) : COMT (catechol-O-methyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Comt (catechol-O-methyltransferase)
Sus scrofa (pig) : COMT (catechol-O-methyltransferase)
Chlorocebus sabaeus (African green monkey) : COMT (catechol-O-methyltransferase)
Heterocephalus glaber (naked mole-rat) : Comt (catechol-O-methyltransferase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2219,941,733 - 19,969,975 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl2219,941,607 - 19,969,975 (+)EnsemblGRCh38hg38GRCh38
GRCh382219,941,772 - 19,969,975 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372219,929,263 - 19,957,498 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362218,309,309 - 18,336,530 (+)NCBINCBI36hg18NCBI36
Build 342218,324,623 - 18,331,084NCBI
Celera223,780,539 - 3,808,699 (+)NCBI
Cytogenetic Map22q11.21NCBI
HuRef223,549,825 - 3,577,976 (+)NCBIHuRef
CHM1_12219,929,027 - 19,957,208 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants