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Gene: COMT (catechol-O-methyltransferase) Homo sapiens
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Symbol: COMT
Name: catechol-O-methyltransferase
Description: Exhibits catechol O-methyltransferase activity. Involved in catecholamine catabolic process. Localizes to the intracellular membrane-bounded organelle. Implicated in several diseases, including attention deficit hyperactivity disorder; bulimia nervosa; cognitive disorder (multiple); eumycotic mycetoma; and reproductive organ cancer (multiple). Biomarker of breast cancer; leiomyoma; ovarian cancer; polycystic ovary syndrome; and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: catechol O-methyltransferase; catechol-O-methyltransferase isoform; epididymis secretory sperm binding protein Li 98n; HEL-S-98n; testicular tissue protein Li 42
Orthologs:
Mus musculus (house mouse) : Comt (catechol-O-methyltransferase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Comt (catechol-O-methyltransferase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Comt (catechol-O-methyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : COMT (catechol-O-methyltransferase)
Canis lupus familiaris (dog) : COMT (catechol-O-methyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Comt (catechol-O-methyltransferase)
Sus scrofa (pig) : COMT (catechol-O-methyltransferase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382219,941,772 - 19,969,975 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372219,929,263 - 19,957,498 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362218,309,309 - 18,336,530 (+)NCBINCBI36hg18NCBI36
Build 342218,324,623 - 18,331,084NCBI
Celera223,780,539 - 3,808,699 (+)NCBI
Cytogenetic Map22q11.21NCBI
HuRef223,549,825 - 3,577,976 (+)NCBIHuRef
CHM1_12219,929,027 - 19,957,208 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on COMT
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737102
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.