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Gene: EGR1 (early growth response 1) Homo sapiens
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Symbol: EGR1
Name: early growth response 1
Description: Exhibits several functions, including double-stranded DNA binding activity; histone acetyltransferase binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including cellular response to cytokine stimulus; regulation of protein sumoylation; and transcription by RNA polymerase II. Localizes to the cytoplasm and nucleoplasm. Implicated in asthma and myeloid neoplasm. Biomarker of several diseases, including Alzheimer's disease; artery disease (multiple); asthma; bone disease (multiple); and lung disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AT225; early growth response protein 1; EGR-1; G0S30; KROX-24; nerve growth factor-induced protein A; NGFI-A; TIS8; transcription factor ETR103; transcription factor Zif268; ZIF-268; zinc finger protein 225; zinc finger protein Krox-24; ZNF225
Orthologs:
Mus musculus (house mouse) : Egr1 (early growth response 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Egr1 (early growth response 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Egr1 (early growth response 1)
Pan paniscus (bonobo/pygmy chimpanzee) : EGR1 (early growth response 1)
Canis lupus familiaris (dog) : EGR1 (early growth response 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Egr1 (early growth response 1)
Sus scrofa (pig) : EGR1 (early growth response 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385138,465,479 - 138,469,303 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375137,801,181 - 137,805,004 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365137,829,080 - 137,832,903 (+)NCBINCBI36hg18NCBI36
Build 345137,829,079 - 137,832,903NCBI
Celera5133,922,029 - 133,925,852 (+)NCBI
Cytogenetic Map5q31.2NCBI
HuRef5132,991,746 - 132,995,569 (+)NCBIHuRef
CHM1_15137,233,931 - 137,237,754 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on EGR1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737111
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.