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Gene: S100B (S100 calcium binding protein B) Homo sapiens
Symbol: S100B
Name: S100 calcium binding protein B
CRRD ID: 737117
Description: Exhibits several functions, including RAGE receptor binding activity; S100 protein binding activity; and protein homodimerization activity. Involved in positive regulation of I-kappaB kinase/NF-kappaB signaling. Localizes to several cellular components, including nucleoplasm; perinuclear region of cytoplasm; and ruffle. Implicated in Alzheimer's disease; Parkinson's disease; aspergillosis; and schizophrenia. Biomarker of several diseases, including West Nile fever; asphyxia neonatorum; autoimmune disease of central nervous system (multiple); bacterial meningitis; and brain disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: NEF; S-100 calcium-binding protein, beta chain; S-100 protein beta chain; S-100 protein subunit beta; S100; S100 beta; S100 calcium binding protein, beta (neural); S100 calcium-binding protein B; S100 calcium-binding protein, beta (neural); s100 protein, beta polypeptide; S100-B; S100beta
Mus musculus (house mouse) : S100b (S100 protein, beta polypeptide, neural)  MGI  Alliance
Rattus norvegicus (Norway rat) : S100b (S100 calcium binding protein B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : S100b (S100 calcium binding protein B)
Pan paniscus (bonobo/pygmy chimpanzee) : S100B (S100 calcium binding protein B)
Canis lupus familiaris (dog) : S100B (S100 calcium binding protein B)
Sus scrofa (pig) : S100B (S100 calcium binding protein B)
Chlorocebus sabaeus (African green monkey) : S100B (S100 calcium binding protein B)
Heterocephalus glaber (naked mole-rat) : S100b (S100 calcium binding protein B)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2146,598,604 - 46,605,208 (-)EnsemblGRCh38hg38GRCh38
GRCh382146,598,604 - 46,605,243 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372148,018,531 - 48,025,035 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362146,842,959 - 46,849,463 (-)NCBINCBI36hg18NCBI36
Build 342146,842,958 - 46,849,424NCBI
Celera2133,131,698 - 33,138,202 (-)NCBI
Cytogenetic Map21q22.3NCBI
HuRef2133,398,429 - 33,404,960 (-)NCBIHuRef
CHM1_12147,579,370 - 47,585,892 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on S100B
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737117
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-09-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.