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Gene: PDGFB (platelet derived growth factor subunit B) Homo sapiens
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Symbol: PDGFB
Name: platelet derived growth factor subunit B
CRRD ID: 737124
Description: Exhibits several functions, including molecular function regulator; platelet-derived growth factor binding activity; and protein dimerization activity. Involved in several processes, including positive regulation of cell migration; positive regulation of cell population proliferation; and positive regulation of cellular metabolic process. Localizes to cell surface. Implicated in basal ganglia calcification; clear cell renal cell carcinoma; connective tissue cancer (multiple); familial meningioma; and prostatic hypertrophy. Biomarker of several diseases, including COVID-19; Kuhnt-Junius degeneration; bone disease (multiple); diabetic retinopathy (multiple); and reproductive organ cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: becaplermin; c-sis; FLJ12858; IBGC5; PDGF subunit B; PDGF, B chain; PDGF-2; PDGF2; platelet-derived growth factor 2; platelet-derived growth factor B chain; platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog); platelet-derived growth factor subunit B; platelet-derived growth factor, B chain; Platelet-derived growth factor, beta polypeptide (oncogene SIS); proto-oncogene c-Sis; SIS; SSV
Orthologs:
Mus musculus (house mouse) : Pdgfb (platelet derived growth factor, B polypeptide)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pdgfb (platelet derived growth factor subunit B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pdgfb (platelet derived growth factor subunit B)
Pan paniscus (bonobo/pygmy chimpanzee) : PDGFB (platelet derived growth factor subunit B)
Canis lupus familiaris (dog) : PDGFB (platelet derived growth factor subunit B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pdgfb (platelet derived growth factor subunit B)
Sus scrofa (pig) : PDGFB (platelet derived growth factor subunit B)
Chlorocebus sabaeus (African green monkey) : PDGFB (platelet derived growth factor subunit B)
Heterocephalus glaber (naked mole-rat) : Pdgfb (platelet derived growth factor subunit B)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2239,223,359 - 39,244,982 (-)EnsemblGRCh38hg38GRCh38
GRCh382239,223,359 - 39,244,982 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372239,619,685 - 39,640,957 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362237,949,665 - 37,970,936 (-)NCBINCBI36hg18NCBI36
Build 342237,944,218 - 37,961,419NCBI
Celera2223,421,845 - 23,443,115 (-)NCBI
Cytogenetic Map22q13.1ENTREZGENE
HuRef2222,586,719 - 22,607,974 (-)NCBIHuRef
CHM1_12239,577,881 - 39,599,570 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Disease Annotations
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References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PDGFB
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737124
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-09-29
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.