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Gene: IGF2 (insulin like growth factor 2) Homo sapiens
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Symbol: IGF2
Name: insulin like growth factor 2
Description: Exhibits signaling receptor binding activity. Involved in positive regulation of activated T cell proliferation; positive regulation of mitotic nuclear division; and positive regulation of signal transduction. Predicted to localize to the extracellular region and platelet alpha granule lumen. Implicated in choriocarcinoma; hepatocellular carcinoma; and rheumatoid arthritis. Biomarker of several diseases, including Lewy body dementia; acquired immunodeficiency syndrome; arthritis (multiple); inflammatory bowel disease (multiple); and neurodegenerative disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C11orf43; FLJ22066; FLJ44734; GRDF; IGF-II; INSIGF; insulin-like growth factor 2 (somatomedin A); insulin-like growth factor II; insulin-like growth factor type 2; PP9974; preptin; putative insulin-like growth factor II associated protein; somatomedin A; somatomedin-A; T3M-11-derived growth factor
Orthologs:
Mus musculus (house mouse) : Igf2 (insulin-like growth factor 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Igf2 (insulin-like growth factor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Igf2 (insulin like growth factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : IGF2 (insulin like growth factor 2)
Canis lupus familiaris (dog) : IGF2 (insulin like growth factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Igf2 (insulin like growth factor 2)
Sus scrofa (pig) : IGF2 (insulin like growth factor 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38112,129,112 - 2,149,603 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37112,150,346 - 2,179,611 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,106,923 - 2,127,409 (-)NCBINCBI36hg18NCBI36
Build 34112,110,531 - 2,116,578NCBI
Celera112,186,838 - 2,207,338 (-)NCBI
Cytogenetic Map11p15.5NCBI
HuRef111,940,869 - 1,961,095 (-)NCBIHuRef
CHM1_1112,148,968 - 2,169,786 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on IGF2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737149
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-10-29
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.