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Gene: FOXO1 (forkhead box O1) Homo sapiens
Symbol: FOXO1
Name: forkhead box O1
CRRD ID: 737155
Description: Exhibits several functions, including DNA-binding transcription factor activity; beta-catenin binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to hyperoxia; positive regulation of catabolic process; and regulation of apoptotic process. Localizes to cytoplasm and nucleus. Implicated in alveolar rhabdomyosarcoma. Biomarker of congestive heart failure; hepatocellular carcinoma; and prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FKH1; FKHR; forkhead box protein O1; forkhead box protein O1A; forkhead homolog in rhabdomyosarcoma; forkhead in rhabdomyosarcoma; forkhead, Drosophila, homolog of, in rhabdomyosarcoma; FOXO1A
Mus musculus (house mouse) : Foxo1 (forkhead box O1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Foxo1 (forkhead box O1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Foxo1 (forkhead box O1)
Pan paniscus (bonobo/pygmy chimpanzee) : FOXO1 (forkhead box O1)
Canis lupus familiaris (dog) : FOXO1 (forkhead box O1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Foxo1 (forkhead box O1)
Sus scrofa (pig) : FOXO1 (forkhead box O1)
Chlorocebus sabaeus (African green monkey) : FOXO1 (forkhead box O1)
Heterocephalus glaber (naked mole-rat) : Foxo1 (forkhead box O1)
more info ...
Related Pseudogenes: FOXO1B  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1340,555,667 - 40,666,641 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1340,469,953 - 40,666,641 (-)EnsemblGRCh38hg38GRCh38
GRCh381340,555,667 - 40,666,641 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371341,129,801 - 41,240,734 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361340,027,801 - 40,138,734 (-)NCBINCBI36hg18NCBI36
Build 341340,027,816 - 40,138,734NCBI
Celera1322,187,272 - 22,298,190 (-)NCBI
Cytogenetic Map13q14.11NCBI
HuRef1321,931,318 - 22,042,054 (-)NCBIHuRef
CHM1_11341,097,585 - 41,208,493 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on FOXO1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737155
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-10-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.