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Gene: FLT1 (fms related receptor tyrosine kinase 1) Homo sapiens
Symbol: FLT1
Name: fms related receptor tyrosine kinase 1
CRRD ID: 737202
Description: Exhibits growth factor binding activity and transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including monocyte chemotaxis; positive regulation of kinase activity; and protein phosphorylation. Localizes to actin cytoskeleton; integral component of plasma membrane; and receptor complex. Implicated in Kuhnt-Junius degeneration; diabetic retinopathy; and pre-eclampsia. Biomarker of several diseases, including Kawasaki disease; Leydig cell tumor; cerebrovascular disease (multiple); kidney cancer (multiple); and retinal disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLT; FLT-1; fms related tyrosine kinase 1; fms-like tyrosine kinase 1; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); tyrosine-protein kinase FRT; tyrosine-protein kinase receptor FLT; vascular endothelial growth factor receptor 1; vascular permeability factor receptor; VEGFR-1; VEGFR1
Mus musculus (house mouse) : Flt1 (FMS-like tyrosine kinase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Flt1 (Fms related receptor tyrosine kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Flt1 (fms related receptor tyrosine kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : FLT1 (fms related receptor tyrosine kinase 1)
Canis lupus familiaris (dog) : FLT1 (fms related receptor tyrosine kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Flt1 (fms related receptor tyrosine kinase 1)
Sus scrofa (pig) : FLT1 (fms related receptor tyrosine kinase 1)
Chlorocebus sabaeus (African green monkey) : FLT1 (fms related receptor tyrosine kinase 1)
Heterocephalus glaber (naked mole-rat) : Flt1 (fms related receptor tyrosine kinase 1)
more info ...
Related Pseudogenes: FLT1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1328,300,346 - 28,495,145 (-)EnsemblGRCh38hg38GRCh38
GRCh381328,300,346 - 28,495,128 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371328,874,483 - 29,069,265 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361327,774,389 - 27,967,265 (-)NCBINCBI36hg18NCBI36
Build 341327,773,789 - 27,967,232NCBI
Celera139,949,266 - 10,144,048 (-)NCBI
Cytogenetic Map13q12.3NCBI
HuRef139,695,411 - 9,890,006 (-)NCBIHuRef
CHM1_11328,842,736 - 29,037,594 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on FLT1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737202
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-11-03
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.