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Gene: FGA (fibrinogen alpha chain) Homo sapiens
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Symbol: FGA
Name: fibrinogen alpha chain
Description: Exhibits structural molecule activity. Contributes to cell adhesion molecule binding activity and signaling receptor binding activity. Involved in several processes, including blood coagulation; negative regulation of apoptotic process; and positive regulation of secretion by cell. Localizes to the external side of plasma membrane; fibrinogen complex; and platelet alpha granule. Implicated in congenital afibrinogenemia; familial visceral amyloidosis; and thrombophilia. Biomarker of Crohn's disease; keratoconus; precursor lymphoblastic lymphoma/leukemia; and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Fib2; fibrinogen, A alpha polypeptide; fibrinogen, alpha polypeptide; MGC119422; MGC119423; MGC119425
Orthologs:
Mus musculus (house mouse) : Fga (fibrinogen alpha chain)  MGI  Alliance
Rattus norvegicus (Norway rat) : Fga (fibrinogen alpha chain)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fga (fibrinogen alpha chain)
Pan paniscus (bonobo/pygmy chimpanzee) : FGA (fibrinogen alpha chain)
Canis lupus familiaris (dog) : FGA (fibrinogen alpha chain)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fga (fibrinogen alpha chain)
Sus scrofa (pig) : FGA (fibrinogen alpha chain)
Chlorocebus sabaeus (African green monkey) : FGA (fibrinogen alpha chain)
Heterocephalus glaber (naked mole-rat) : Fga (fibrinogen alpha chain)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl4154,583,128 - 154,590,745 (-)EnsemblGRCh38hg38GRCh38
GRCh384154,583,126 - 154,590,742 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374155,504,280 - 155,511,897 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364155,723,730 - 155,731,347 (-)NCBINCBI36hg18NCBI36
Build 344155,864,033 - 155,869,470NCBI
Celera4152,835,246 - 152,842,862 (-)NCBI
Cytogenetic Map4q31.3NCBI
HuRef4151,244,861 - 151,252,473 (-)NCBIHuRef
CHM1_14155,482,199 - 155,489,839 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on FGA
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737209
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-03-10
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.