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Gene: Cyp17a1 (cytochrome P450, family 17, subfamily a, polypeptide 1) Mus musculus
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Symbol: Cyp17a1
Name: cytochrome P450, family 17, subfamily a, polypeptide 1
CRRD ID: 737222
Description: Exhibits steroid 17-alpha-monooxygenase activity. Involved in glucocorticoid biosynthetic process. Localizes to axon and neuronal cell body. Is expressed in several structures, including adrenal gland; gut; nervous system; reproductive system; and retina layer. Human ortholog(s) of this gene implicated in several diseases, including cholelithiasis; congenital adrenal hyperplasia; gallbladder cancer; osteoporosis; and prostate cancer. Orthologous to human CYP17A1 (cytochrome P450 family 17 subfamily A member 1); PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 17-alpha-hydroxyprogesterone aldolase; Cyp1; Cyp17; CYPXVII; cytochrome P450 17A1; cytochrome P450, 17; cytochrome P450, 17a1; cytochrome P450-C17; cytochrome P450c17; p450c1; p450c17; steroid 17-alpha hydroxylase; steroid 17-alpha-hydroxylase/17,20 lyase; steroid 17-alpha-monooxygenase
Orthologs:
Homo sapiens (human) : CYP17A1 (cytochrome P450 family 17 subfamily A member 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cyp17a1 (cytochrome P450, family 17, subfamily a, polypeptide 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102011010 (steroid 17-alpha-hydroxylase/17,20 lyase)
Pan paniscus (bonobo/pygmy chimpanzee) : CYP17A1 (cytochrome P450 family 17 subfamily A member 1)
Canis lupus familiaris (dog) : CYP17A1 (cytochrome P450 family 17 subfamily A member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101970767 (steroid 17-alpha-hydroxylase/17,20 lyase)
Sus scrofa (pig) : CYP17A1 (cytochrome P450 17A1)
Chlorocebus sabaeus (African green monkey) : CYP17A1 (cytochrome P450 family 17 subfamily A member 1)
Heterocephalus glaber (naked mole-rat) : LOC101726496 (steroid 17-alpha-hydroxylase/17,20 lyase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1946,667,165 - 46,673,172 (-)EnsemblGRCm38mm10GRCm38
GRCm381946,667,165 - 46,673,000 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371946,741,655 - 46,747,490 (-)NCBIGRCm37mm9NCBIm37
MGSCv361946,720,491 - 46,726,285 (-)NCBImm8
Celera1947,437,171 - 47,443,006 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.97NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Cyp17a1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737222
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.