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Gene: CXCL12 (C-X-C motif chemokine ligand 12) Homo sapiens
Symbol: CXCL12
Name: C-X-C motif chemokine ligand 12
Description: Exhibits CXCR chemokine receptor binding activity; chemokine activity; and integrin binding activity. Involved in several processes, including integrin activation; negative regulation of apoptotic process; and regulation of leukocyte migration. Localizes to the collagen-containing extracellular matrix and extracellular exosome. Implicated in breast carcinoma; diabetic angiopathy; human immunodeficiency virus infectious disease; and type 1 diabetes mellitus. Biomarker of diabetic retinopathy; insulinoma; periodontitis; and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: chemokine (C-X-C motif) ligand 12; intercrine reduced in hepatomas; IRH; PBSF; pre-B cell growth-stimulating factor; SCYB12; SDF-1a; SDF-1b; SDF1; SDF1A; SDF1B; stromal cell-derived factor 1; TLSF; TLSF-a; TLSF-b; TPAR1
Mus musculus (house mouse) : Cxcl12 (chemokine (C-X-C motif) ligand 12)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cxcl12 (C-X-C motif chemokine ligand 12)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cxcl12 (C-X-C motif chemokine ligand 12)
Pan paniscus (bonobo/pygmy chimpanzee) : CXCL12 (C-X-C motif chemokine ligand 12)
Canis lupus familiaris (dog) : CXCL12 (C-X-C motif chemokine ligand 12)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cxcl12 (C-X-C motif chemokine ligand 12)
Sus scrofa (pig) : CXCL12 (C-X-C motif chemokine ligand 12)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1044,370,165 - 44,386,493 (-)Ensembl
GRCh381044,292,088 - 44,385,097 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371044,865,601 - 44,880,545 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361044,185,611 - 44,200,548 (-)NCBINCBI36hg18NCBI36
Build 341044,192,516 - 44,200,551NCBI
Celera1040,869,153 - 40,884,099 (-)NCBI
Cytogenetic Map10q11.21NCBI
HuRef1041,391,945 - 41,406,899 (-)NCBIHuRef
CHM1_11044,904,782 - 44,919,728 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CXCL12
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737223
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-01-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.