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Gene: VAV1 (vav guanine nucleotide exchange factor 1) Homo sapiens
Symbol: VAV1
Name: vav guanine nucleotide exchange factor 1
Description: Exhibits guanyl-nucleotide exchange factor activity and phosphotyrosine residue binding activity. Involved in regulation of GTPase activity and regulation of cell size. Predicted to localize to the cytosol and plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: oncogene vav; proto-oncogene vav; VAV; vav 1 guanine nucleotide exchange factor; vav 1 oncogene; vav proto-oncogene
Mus musculus (house mouse) : Vav1 (vav 1 oncogene)  MGI  Alliance
Rattus norvegicus (Norway rat) : Vav1 (vav guanine nucleotide exchange factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Vav1 (vav guanine nucleotide exchange factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : VAV1 (vav guanine nucleotide exchange factor 1)
Canis lupus familiaris (dog) : VAV1 (vav guanine nucleotide exchange factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Vav1 (vav guanine nucleotide exchange factor 1)
Sus scrofa (pig) : VAV1 (vav guanine nucleotide exchange factor 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38196,772,708 - 6,857,366 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37196,772,679 - 6,857,377 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36196,723,722 - 6,808,371 (+)NCBINCBI36hg18NCBI36
Build 34196,723,721 - 6,808,371NCBI
Celera196,714,968 - 6,799,596 (+)NCBI
Cytogenetic Map19p13.3NCBI
HuRef196,535,153 - 6,619,808 (+)NCBIHuRef
CHM1_1196,772,530 - 6,857,195 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on VAV1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737234
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.