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Gene: ACVRL1 (activin A receptor like type 1) Homo sapiens
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Symbol: ACVRL1
Name: activin A receptor like type 1
CRRD ID: 737253
Description: Exhibits several functions, including ATP binding activity; activin binding activity; and transmembrane receptor protein serine/threonine kinase activity. Involved in several processes, including endothelium development; positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and transmembrane receptor protein serine/threonine kinase signaling pathway. Localizes to cell surface and integral component of plasma membrane. Implicated in hereditary hemorrhagic telangiectasia and pulmonary hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: activin A receptor type II-like 1; activin A receptor type IL; activin A receptor, type II-like kinase 1; activin receptor-like kinase 1; ACVRLK1; ALK-1; ALK1; HHT; HHT2; ORW2; serine/threonine-protein kinase receptor R3; SKR3; TGF-B superfamily receptor type I; TSR-I
Orthologs:
Mus musculus (house mouse) : Acvrl1 (activin A receptor, type II-like 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Acvrl1 (activin A receptor like type 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Acvrl1 (activin A receptor like type 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ACVRL1 (activin A receptor like type 1)
Canis lupus familiaris (dog) : ACVRL1 (activin A receptor like type 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Acvrl1 (activin A receptor like type 1)
Sus scrofa (pig) : ACVRL1 (activin A receptor like type 1)
Chlorocebus sabaeus (African green monkey) : ACVRL1 (activin A receptor like type 1)
Heterocephalus glaber (naked mole-rat) : Acvrl1 (activin A receptor like type 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1251,906,908 - 51,923,361 (+)EnsemblGRCh38hg38GRCh38
GRCh381251,906,913 - 51,923,361 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371252,300,657 - 52,317,145 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361250,587,469 - 50,603,412 (+)NCBINCBI36hg18NCBI36
Build 341250,587,468 - 50,601,120NCBI
Celera1251,103,338 - 51,119,286 (+)NCBI
Cytogenetic Map12q13.13ENTREZGENE
HuRef1249,334,280 - 49,350,228 (+)NCBIHuRef
CHM1_11252,267,590 - 52,283,516 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Nomenclature History
 
More on ACVRL1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737253
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.