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Gene: CA2 (carbonic anhydrase 2) Homo sapiens
Symbol: CA2
Name: carbonic anhydrase 2
Description: Exhibits arylesterase activity; carbonate dehydratase activity; and zinc ion binding activity. Involved in angiotensin-activated signaling pathway and regulation of anion transport. Localizes to apical part of cell; cytoplasm; and plasma membrane. Implicated in autosomal recessive osteopetrosis 3 and osteopetrosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CA-II; CAC; CAII; Car2; carbonate dehydratase II; carbonic anhydrase B; carbonic anhydrase C; carbonic anhydrase II; carbonic dehydratase; epididymis luminal protein 76; epididymis secretory protein Li 282; HEL-76; HEL-S-282
Mus musculus (house mouse) : Car2 (carbonic anhydrase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Car2 (carbonic anhydrase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ca2 (carbonic anhydrase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CA2 (carbonic anhydrase 2)
Canis lupus familiaris (dog) : CA2 (carbonic anhydrase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ca2 (carbonic anhydrase 2)
Sus scrofa (pig) : CA2 (carbonic anhydrase 2)
Chlorocebus sabaeus (African green monkey) : CA2 (carbonic anhydrase 2)
Heterocephalus glaber (naked mole-rat) : Ca2 (carbonic anhydrase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl885,463,968 - 85,481,493 (+)EnsemblGRCh38hg38GRCh38
GRCh38885,463,902 - 85,481,493 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37886,376,131 - 86,393,721 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36886,563,383 - 86,580,973 (+)NCBINCBI36hg18NCBI36
Build 34886,563,497 - 86,580,973NCBI
Celera882,381,194 - 82,398,781 (+)NCBI
Cytogenetic Map8q21.2NCBI
HuRef881,870,322 - 81,887,902 (+)NCBIHuRef
CHM1_1886,427,817 - 86,445,411 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CA2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737257
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.