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Gene: PPARA (peroxisome proliferator activated receptor alpha) Homo sapiens
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Symbol: PPARA
Name: peroxisome proliferator activated receptor alpha
CRRD ID: 737309
Description: Exhibits several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II repressing transcription factor binding activity; and ubiquitin conjugating enzyme binding activity. Involved in several processes, including negative regulation of lipid storage; negative regulation of macrophage derived foam cell differentiation; and regulation of nucleobase-containing compound metabolic process. Localizes to nucleoplasm. Implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Biomarker of cystic fibrosis and fatty liver disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: hPPAR; MGC2237; MGC2452; NR1C1; nuclear receptor subfamily 1 group C member 1; peroxisome proliferative activated receptor, alpha; peroxisome proliferator-activated nuclear receptor alpha variant 3; peroxisome proliferator-activated receptor alpha; PPAR; PPAR-alpha; PPARalpha
Orthologs:
Mus musculus (house mouse) : Ppara (peroxisome proliferator activated receptor alpha)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ppara (peroxisome proliferator activated receptor alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ppara (peroxisome proliferator activated receptor alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : PPARA (peroxisome proliferator activated receptor alpha)
Canis lupus familiaris (dog) : PPARA (peroxisome proliferator activated receptor alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ppara (peroxisome proliferator activated receptor alpha)
Sus scrofa (pig) : PPARA (peroxisome proliferator activated receptor alpha)
Chlorocebus sabaeus (African green monkey) : PPARA (peroxisome proliferator activated receptor alpha)
Heterocephalus glaber (naked mole-rat) : Ppara (peroxisome proliferator activated receptor alpha)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2246,150,521 - 46,243,756 (+)EnsemblGRCh38hg38GRCh38
GRCh382246,150,526 - 46,243,756 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372246,546,458 - 46,639,653 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362244,925,163 - 45,018,317 (+)NCBINCBI36hg18NCBI36
Build 342244,893,181 - 44,937,060NCBI
Celera2230,453,877 - 30,547,038 (+)NCBI
Cytogenetic Map22q13.31ENTREZGENE
HuRef2229,490,745 - 29,583,687 (+)NCBIHuRef
CHM1_12246,506,503 - 46,598,389 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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