Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: PROC (protein C, inactivator of coagulation factors Va and VIIIa) Homo sapiens
Symbol: PROC
Name: protein C, inactivator of coagulation factors Va and VIIIa
CRRD ID: 737321
Description: Exhibits serine-type endopeptidase activity. Involved in several processes, including negative regulation of coagulation; negative regulation of inflammatory response; and positive regulation of establishment of endothelial barrier. Localizes to Golgi apparatus and endoplasmic reticulum. Implicated in several diseases, including antiphospholipid syndrome; artery disease (multiple); placental abruption; thrombophilia (multiple); and toxic shock syndrome. Biomarker of disseminated intravascular coagulation; myocardial infarction; osteonecrosis; pulmonary embolism; and thrombotic thrombocytopenic purpura.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: activated protein C; anticoagulant protein C; APC; autoprothrombin IIA; blood coagulation factor XIV; PC; prepro-protein C; PROC1; protein c; THPH3; THPH4; type I protein C; vitamin K-dependent protein C
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: PROC (Gene ID: 5624) and APC (Gene ID: 324) loci share the APC symbol/alias in common. [08 Feb 2019]
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2127,418,427 - 127,429,246 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl2127,418,427 - 127,429,242 (+)EnsemblGRCh38hg38GRCh38
GRCh382127,418,143 - 127,429,246 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372128,175,996 - 128,186,822 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362127,892,487 - 127,903,288 (+)NCBINCBI36hg18NCBI36
Build 342127,892,245 - 127,903,048NCBI
Celera2121,487,217 - 121,498,043 (+)NCBI
Cytogenetic Map2q14.3NCBI
HuRef2120,483,060 - 120,493,885 (+)NCBIHuRef
CHM1_12128,180,576 - 128,191,401 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PROC
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737321
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.