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Gene: SOST (sclerostin) Homo sapiens
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Symbol: SOST
Name: sclerostin
Description: Exhibits transcription factor binding activity. Involved in several processes, including cellular response to parathyroid hormone stimulus; negative regulation of canonical Wnt signaling pathway; and regulation of transcription, DNA-templated. Colocalizes with the collagen-containing extracellular matrix. Implicated in SOST-related sclerosing bone dysplasia; sclerosteosis; and sclerosteosis 1.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CDD; DAND6; SOST1; VBCH
Orthologs:
Mus musculus (house mouse) : Sost (sclerostin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sost (sclerostin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sost (sclerostin)
Pan paniscus (bonobo/pygmy chimpanzee) : SOST (sclerostin)
Canis lupus familiaris (dog) : SOST (sclerostin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sost (sclerostin)
Sus scrofa (pig) : SOST (sclerostin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381743,753,738 - 43,758,791 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371741,831,099 - 41,836,156 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361739,186,625 - 39,191,682 (-)NCBINCBI36hg18NCBI36
Build 341739,186,624 - 39,191,682NCBI
Celera1738,539,106 - 38,544,164 (-)NCBI
Cytogenetic Map17q21.31NCBI
HuRef1737,595,207 - 37,600,265 (-)NCBIHuRef
CHM1_11742,066,723 - 42,071,781 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SOST
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737334
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-13
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.