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Gene: GRIA3 (glutamate ionotropic receptor AMPA type subunit 3) Homo sapiens
Symbol: GRIA3
Name: glutamate ionotropic receptor AMPA type subunit 3
Description: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AMPA-selective glutamate receptor 3; dJ1171F9.1; GluA3; gluR-3; GLUR-C; GLUR-K3; GLUR3; GLURC; glutamate receptor 3; glutamate receptor C; glutamate receptor ionotropic, AMPA 3; glutamate receptor subunit 3; glutamate receptor, ionotrophic, AMPA 3; glutamate receptor, ionotropic, AMPA 3; glutamate receptor, ionotropic, ampa3 (alpha 3); MRX94
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X123,184,243 - 123,490,915 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X122,317,996 - 122,624,766 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X122,145,777 - 122,452,447 (+)NCBINCBI36hg18NCBI36
Build 34X122,043,692 - 122,064,066NCBI
CeleraX122,704,041 - 123,010,712 (+)NCBI
Cytogenetic MapXq25NCBI
HuRefX111,704,466 - 112,009,621 (+)NCBIHuRef
CHM1_1X122,228,980 - 122,535,894 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on GRIA3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737336
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.