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Gene: MME (membrane metalloendopeptidase) Homo sapiens
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Symbol: MME
Name: membrane metalloendopeptidase
Description: Exhibits several functions, including peptidase activity, acting on L-amino acid peptides; phospholipid binding activity; and protein homodimerization activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; cellular response to UV; and neuropeptide processing. Localizes to several cellular components, including the brush border; early endosome; and trans-Golgi network. Implicated in Alzheimer's disease; Charcot-Marie-Tooth disease axonal type 2T; cerebral amyloid angiopathy; hereditary ataxia; and membranous glomerulonephritis. Biomarker of cerebral amyloid angiopathy and periodontitis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: atriopeptidase; CALLA; CD10; CMT2T; common acute lymphocytic leukemia antigen; DKFZp686O16152; enkephalinase; membrane metallo endopeptidase; membrane metallo-endopeptidase; membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase); membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10); membrane metallo-endopeptidase variant 1; membrane metallo-endopeptidase variant 2; MGC126681; MGC126707; NEP; neprilysin; neprilysin-390; neprilysin-411; neutral endopeptidase 24.11; SCA43; SFE; skin fibroblast elastase
Orthologs:
Mus musculus (house mouse) : Mme (membrane metallo endopeptidase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mme (membrane metallo-endopeptidase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mme (membrane metalloendopeptidase)
Pan paniscus (bonobo/pygmy chimpanzee) : MME (membrane metalloendopeptidase)
Canis lupus familiaris (dog) : MME (membrane metalloendopeptidase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mme (membrane metalloendopeptidase)
Sus scrofa (pig) : MME (membrane metalloendopeptidase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383155,024,124 - 155,183,729 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373154,797,436 - 154,901,518 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363156,280,130 - 156,384,212 (+)NCBINCBI36hg18NCBI36
Build 343156,280,756 - 156,384,194NCBI
Celera3153,217,556 - 153,321,523 (+)NCBI
Cytogenetic Map3q25.2NCBI
HuRef3152,191,860 - 152,295,862 (+)NCBIHuRef
CHM1_13154,760,481 - 154,864,540 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Protein Structures
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on MME
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737353
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.