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Gene: F3 (coagulation factor III, tissue factor) Homo sapiens
Symbol: F3
Name: coagulation factor III, tissue factor
Description: Exhibits phospholipid binding activity and protease binding activity. Contributes to serine-type endopeptidase activity. Involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of plasma proteins involved in acute inflammatory response; and positive regulation of signal transduction. Localizes to several cellular components, including the cell surface; extracellular space; and serine-type peptidase complex. Implicated in disseminated intravascular coagulation; precursor B lymphoblastic lymphoma/leukemia; and von Willebrand's disease. Biomarker of several diseases, including acute pancreatitis; diabetes mellitus (multiple); hematologic cancer (multiple); lung disease (multiple); and thrombosis (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD142; coagulation factor 3; coagulation factor III (thromboplastin, tissue factor); FLJ17960; TF; TFA; thromboplastin; tissue factor
Mus musculus (house mouse) : F3 (coagulation factor III)  MGI  Alliance
Rattus norvegicus (Norway rat) : F3 (coagulation factor III, tissue factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : F3 (coagulation factor III, tissue factor)
Pan paniscus (bonobo/pygmy chimpanzee) : F3 (coagulation factor III, tissue factor)
Canis lupus familiaris (dog) : F3 (coagulation factor III, tissue factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : F3 (coagulation factor III, tissue factor)
Sus scrofa (pig) : F3 (coagulation factor III, tissue factor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl194,529,173 - 94,541,759 (-)Ensembl
GRCh38194,529,173 - 94,541,857 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37194,994,732 - 95,007,413 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,767,461 - 94,779,903 (-)NCBINCBI36hg18NCBI36
Build 34194,706,893 - 94,719,336NCBI
Celera193,249,195 - 93,261,871 (-)NCBI
Cytogenetic Map1p21.3NCBI
HuRef193,116,432 - 93,129,108 (-)NCBIHuRef
CHM1_1195,109,584 - 95,122,259 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on F3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737354
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.