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Gene: LCAT (lecithin-cholesterol acyltransferase) Homo sapiens
Symbol: LCAT
Name: lecithin-cholesterol acyltransferase
CRRD ID: 737383
Description: Exhibits 1-alkyl-2-acetylglycerophosphocholine esterase activity; apolipoprotein A-I binding activity; and transferase activity, transferring acyl groups other than amino-acyl groups. Involved in several processes, including cholesterol esterification; cholesterol homeostasis; and plasma lipoprotein particle remodeling. Localizes to high-density lipoprotein particle. Implicated in Norum disease and arteriosclerosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 1-alkyl-2-acetylglycerophosphocholine esterase; lecithin cholesterol acyltransferase; PAF acetylhydrolase; phosphatidylcholine--sterol O-acyltransferase; phosphatidylcholine-sterol acyltransferase; phospholipid-cholesterol acyltransferase; platelet-activating factor acetylhydrolase; testicular secretory protein Li 24
Mus musculus (house mouse) : Lcat (lecithin cholesterol acyltransferase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Lcat (lecithin cholesterol acyltransferase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lcat (lecithin-cholesterol acyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : LCAT (lecithin-cholesterol acyltransferase)
Canis lupus familiaris (dog) : LCAT (lecithin-cholesterol acyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lcat (lecithin-cholesterol acyltransferase)
Sus scrofa (pig) : LCAT (lecithin-cholesterol acyltransferase)
Chlorocebus sabaeus (African green monkey) : LCAT (lecithin-cholesterol acyltransferase)
Heterocephalus glaber (naked mole-rat) : Lcat (lecithin-cholesterol acyltransferase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1667,939,750 - 67,944,131 (-)EnsemblGRCh38hg38GRCh38
GRCh381667,939,750 - 67,944,120 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371667,973,787 - 67,978,656 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361666,531,288 - 66,535,516 (-)NCBINCBI36hg18NCBI36
Build 341666,531,287 - 66,535,516NCBI
Celera1652,482,244 - 52,486,472 (-)NCBI
Cytogenetic Map16q22.1NCBI
HuRef1653,847,357 - 53,851,585 (-)NCBIHuRef
CHM1_11669,381,858 - 69,386,086 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on LCAT
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737383
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-09-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.