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Gene: LCAT (lecithin-cholesterol acyltransferase) Homo sapiens
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Symbol: LCAT
Name: lecithin-cholesterol acyltransferase
Description: Exhibits apolipoprotein A-I binding activity and phosphatidylcholine-sterol O-acyltransferase activity. Involved in several processes, including cholesterol esterification; cholesterol homeostasis; and plasma lipoprotein particle remodeling. Localizes to the high-density lipoprotein particle. Implicated in Norum disease and arteriosclerosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: lecithin cholesterol acyltransferase; phosphatidylcholine--sterol O-acyltransferase; phosphatidylcholine-sterol acyltransferase; phospholipid-cholesterol acyltransferase; testicular secretory protein Li 24
Orthologs:
Mus musculus (house mouse) : Lcat (lecithin cholesterol acyltransferase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Lcat (lecithin cholesterol acyltransferase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lcat (lecithin-cholesterol acyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : LCAT (lecithin-cholesterol acyltransferase)
Canis lupus familiaris (dog) : LCAT (lecithin-cholesterol acyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lcat (lecithin-cholesterol acyltransferase)
Sus scrofa (pig) : LCAT (lecithin-cholesterol acyltransferase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381667,939,750 - 67,944,120 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371667,973,787 - 67,978,656 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361666,531,288 - 66,535,516 (-)NCBINCBI36hg18NCBI36
Build 341666,531,287 - 66,535,516NCBI
Celera1652,482,244 - 52,486,472 (-)NCBI
Cytogenetic Map16q22.1NCBI
HuRef1653,847,357 - 53,851,585 (-)NCBIHuRef
CHM1_11669,381,858 - 69,386,086 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on LCAT
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737383
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.