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Gene: CDH1 (cadherin 1) Homo sapiens
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Symbol: CDH1
Name: cadherin 1
Description: Exhibits several functions, including GTPase activating protein binding activity; ankyrin binding activity; and beta-catenin binding activity. Involved in several processes, including cellular response to indole-3-methanol; cellular response to lithium ion; and positive regulation of protein import into nucleus. Localizes to several cellular components, including the catenin complex; flotillin complex; and lateral plasma membrane. Colocalizes with the cortical actin cytoskeleton. Implicated in several diseases, including blepharocheilodontic syndrome 1; breast cancer (multiple); carcinoma (multiple); cervix uteri carcinoma in situ; and reproductive organ cancer (multiple). Biomarker of several diseases, including gastrointestinal system cancer (multiple); invasive lobular carcinoma; prostate cancer; pulmonary fibrosis; and thyroid gland papillary carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Arc-1; BCDS1; cadherin 1, E-cadherin (epithelial); cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin-1; calcium-dependent adhesion protein, epithelial; CAM 120/80; CD324; CDHE; cell-CAM 120/80; E-Cadherin; E-cadherin 1; ECAD; epithelial cadherin; LCAM; UVO; uvomorulin
Orthologs:
Mus musculus (house mouse) : Cdh1 (cadherin 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cdh1 (cadherin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdh1 (cadherin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : CDH1 (cadherin 1)
Canis lupus familiaris (dog) : CDH1 (cadherin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cdh1 (cadherin 1)
Sus scrofa (pig) : CDH1 (cadherin 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: CDH1 (GeneID 999) and FZR1 (GeneID 51343) share the CDH1 symbol. CDH1 is sometimes used as an abbreviation for 'CDC20 homolog 1' which is an alternate name for the FZR1 gene and thus can be confused with the official symbol for cadherin 1 (CDH1). [16 Jul 2018]
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1668,737,292 - 68,835,541 (+)Ensembl
GRCh381668,737,292 - 68,835,537 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371668,771,128 - 68,869,445 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361667,328,696 - 67,426,945 (+)NCBINCBI36hg18NCBI36
Build 341667,328,695 - 67,426,945NCBI
Celera1653,280,506 - 53,378,750 (+)NCBI
Cytogenetic Map16q22.1NCBI
HuRef1654,643,861 - 54,742,830 (+)NCBIHuRef
CHM1_11670,179,152 - 70,277,602 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model