Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2) Homo sapiens
Analyze
Symbol: HSD11B2
Name: hydroxysteroid 11-beta dehydrogenase 2
CRRD ID: 737468
Description: Predicted to have 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity; NAD binding activity; and steroid binding activity. Predicted to be involved in glucocorticoid biosynthetic process. Predicted to localize to endoplasmic reticulum membrane. Implicated in apparent mineralocorticoid excess syndrome; hypertension; inherited metabolic disorder; obesity; and type 1 diabetes mellitus. Biomarker of type 1 diabetes mellitus and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: -HSD11 type II; 11-beta-HSD; 11-beta-HSD type II; 11-beta-HSD2; 11-beta-hydroxysteroid dehydrogenase type 2; 11-beta-hydroxysteroid dehydrogenase type II; 11-DH2; 11-HSD type II; AME; AME1; corticosteroid 11-beta-dehydrogenase isozyme 2; HSD11K; HSD2; hydroxysteroid (11-beta) dehydrogenase 2; NAD-dependent 11-beta-hydroxysteroid dehydrogenase; SDR9C3; short chain dehydrogenase/reductase family 9C member 3
Orthologs:
Mus musculus (house mouse) : Hsd11b2 (hydroxysteroid 11-beta dehydrogenase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hsd11b2 (hydroxysteroid 11-beta dehydrogenase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hsd11b2 (hydroxysteroid 11-beta dehydrogenase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2)
Canis lupus familiaris (dog) : HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hsd11b2 (hydroxysteroid 11-beta dehydrogenase 2)
Sus scrofa (pig) : HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2)
Chlorocebus sabaeus (African green monkey) : HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2)
Heterocephalus glaber (naked mole-rat) : Hsd11b2 (hydroxysteroid 11-beta dehydrogenase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1667,430,652 - 67,437,553 (+)EnsemblGRCh38hg38GRCh38
GRCh381667,431,121 - 67,437,553 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371667,465,036 - 67,471,456 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361666,022,537 - 66,028,957 (+)NCBINCBI36hg18NCBI36
Build 341666,022,536 - 66,028,953NCBI
Celera1651,973,237 - 51,979,660 (+)NCBI
Cytogenetic Map16q22.1NCBI
HuRef1653,338,306 - 53,344,605 (+)NCBIHuRef
CHM1_11668,872,417 - 68,878,837 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on HSD11B2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737468
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.