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Gene: RNF4 (ring finger protein 4) Homo sapiens
Symbol: RNF4
Name: ring finger protein 4
Description: Exhibits identical protein binding activity. Involved in several processes, including proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of organelle assembly; and response to arsenic-containing substance. Localizes to cytoplasm; microtubule end; and nuclear body. Colocalizes with PML body. Biomarker of Angelman syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: E3 ubiquitin ligase RNF4; E3 ubiquitin-protein ligase RNF4; RES4-26; RING-type E3 ubiquitin transferase RNF4; SLX5; small nuclear RING finger protein; SNURF
Mus musculus (house mouse) : Rnf4 (ring finger protein 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rnf4 (ring finger protein 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rnf4 (ring finger protein 4)
Pan paniscus (bonobo/pygmy chimpanzee) : RNF4 (ring finger protein 4)
Canis lupus familiaris (dog) : RNF4 (ring finger protein 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rnf4 (ring finger protein 4)
Sus scrofa (pig) : RNF4 (ring finger protein 4)
Chlorocebus sabaeus (African green monkey) : RNF4 (ring finger protein 4)
Heterocephalus glaber (naked mole-rat) : Rnf4 (ring finger protein 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl42,462,220 - 2,625,320 (+)EnsemblGRCh38hg38GRCh38
GRCh3842,469,106 - 2,515,859 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3742,470,795 - 2,517,586 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3642,440,605 - 2,487,382 (+)NCBINCBI36hg18NCBI36
Build 3442,438,037 - 2,484,812NCBI
Celera42,381,995 - 2,428,665 (+)NCBI
Cytogenetic Map4p16.3NCBI
HuRef42,410,726 - 2,457,392 (+)NCBIHuRef
CHM1_142,468,951 - 2,515,567 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on RNF4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737478
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.