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Gene: BIRC5 (baculoviral IAP repeat containing 5) Homo sapiens
Symbol: BIRC5
Name: baculoviral IAP repeat containing 5
Description: Exhibits several functions, including chaperone binding activity; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; and protein dimerization activity. Involved in several processes, including G2/M transition of mitotic cell cycle; negative regulation of nitrogen compound metabolic process; and regulation of mitotic nuclear division. Localizes to several cellular components, including the chromosome; microtubule cytoskeleton; and midbody. Implicated in prostate cancer and transitional cell carcinoma. Biomarker of several diseases, including ductal carcinoma in situ; endometrial hyperplasia; prostate cancer; pulmonary hypertension; and urinary system cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: API4; apoptosis inhibitor 4; apoptosis inhibitor survivin; baculoviral IAP repeat-containing 5; baculoviral IAP repeat-containing protein 5; EPR-1; survivin variant 3 alpha
Mus musculus (house mouse) : Birc5 (baculoviral IAP repeat-containing 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Birc5 (baculoviral IAP repeat-containing 5)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : BIRC5 (baculoviral IAP repeat containing 5)
Canis lupus familiaris (dog) : BIRC5 (baculoviral IAP repeat containing 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Birc5 (baculoviral IAP repeat containing 5)
Sus scrofa (pig) : BIRC5 (baculoviral IAP repeat containing 5)
Chlorocebus sabaeus (African green monkey) : BIRC5 (baculoviral IAP repeat containing 5)
Heterocephalus glaber (naked mole-rat) : Birc5 (baculoviral IAP repeat containing 5)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1778,214,186 - 78,225,636 (+)Ensembl
GRCh381778,214,253 - 78,225,635 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371776,210,277 - 76,221,716 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361773,721,872 - 73,733,311 (+)NCBINCBI36hg18NCBI36
Build 341773,721,871 - 73,733,310NCBI
Celera1772,806,306 - 72,817,744 (+)NCBI
Cytogenetic Map17q25.3NCBI
HuRef1771,634,433 - 71,645,847 (+)NCBIHuRef
CHM1_11776,274,801 - 76,286,240 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on BIRC5
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737482
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-02-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.