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Gene: SYP (synaptophysin) Homo sapiens
Symbol: SYP
Name: synaptophysin
Description: This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with an X-linked form of cognitive disability. [provided by RefSeq, Jul 2017]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: major synaptic vesicle protein P38; MRX96; MRXSYP
Mus musculus (house mouse) : Syp (synaptophysin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Syp (synaptophysin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Syp (synaptophysin)
Pan paniscus (bonobo/pygmy chimpanzee) : SYP (synaptophysin)
Canis lupus familiaris (dog) : SYP (synaptophysin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Syp (synaptophysin)
Sus scrofa (pig) : SYP (synaptophysin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X49,187,812 - 49,200,202 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X49,044,263 - 49,056,661 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X48,931,209 - 48,943,605 (-)NCBINCBI36hg18NCBI36
Build 34X48,800,635 - 48,813,032NCBI
CeleraX52,607,708 - 52,620,104 (+)NCBI
Cytogenetic MapXp11.23NCBI
HuRefX46,701,336 - 46,713,608 (-)NCBIHuRef
CHM1_1X49,076,586 - 49,088,982 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on SYP
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737494
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.