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Gene: STAT3 (signal transducer and activator of transcription 3) Homo sapiens
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Symbol: STAT3
Name: signal transducer and activator of transcription 3
CRRD ID: 737517
Description: Exhibits several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II repressing transcription factor binding activity; and nucleic acid binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of gene expression; and regulation of cellular protein metabolic process. Localizes to RNA polymerase II transcription regulator complex; cytosol; and nuclear lumen. Implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); hyper IgE recurrent infection syndrome 1; reproductive organ cancer (multiple); and type 2 diabetes mellitus. Biomarker of several diseases, including Churg-Strauss syndrome; cervix uteri carcinoma in situ; chronic lymphocytic leukemia; kidney cancer (multiple); and lung disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: acute-phase response factor; ADMIO; ADMIO1; APRF; DNA-binding protein APRF; FLJ20882; HIES; MGC16063; signal transducer and activator of transcription 3 (acute-phase response factor)
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1742,313,324 - 42,388,482 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1742,313,324 - 42,388,568 (-)EnsemblGRCh38hg38GRCh38
GRCh381742,313,324 - 42,388,502 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371740,465,342 - 40,540,586 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,718,869 - 37,794,039 (-)NCBINCBI36hg18NCBI36
Build 341737,718,868 - 37,794,039NCBI
Celera1737,120,227 - 37,194,843 (-)NCBI
Cytogenetic Map17q21.2NCBI
HuRef1736,230,024 - 36,304,785 (-)NCBIHuRef
CHM1_11740,701,045 - 40,776,137 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated