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Gene: Cyp19a1 (cytochrome P450, family 19, subfamily a, polypeptide 1) Mus musculus
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Symbol: Cyp19a1
Name: cytochrome P450, family 19, subfamily a, polypeptide 1
CRRD ID: 737520
Description: Exhibits oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Involved in several processes, including negative regulation of response to external stimulus; reproductive structure development; and testosterone biosynthetic process. Predicted to localize to several cellular components, including dendritic spine; neuronal cell body; and synaptic vesicle. Is expressed in central nervous system; early conceptus; gonad; and retina. Used to study Sjogren's syndrome and aromatase excess syndrome. Human ortholog(s) of this gene implicated in several diseases, including aromatase excess syndrome; bladder neck obstruction; endometriosis (multiple); ovarian disease (multiple); and prostate disease (multiple). Orthologous to human CYP19A1 (cytochrome P450 family 19 subfamily A member 1); PARTICIPATES IN aromatase inhibitor pathway; estradiol biosynthetic pathway; steroid hormone biosynthetic pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A; Ar; ArKO; aro; aromatase; Cyp1; Cyp19; CYPXIX; cytochrome P-450AROM; cytochrome P450 19A1; cytochrome P450, 19, aromatase; estrogen synthase; In; Int; Int-5; Int5; MGC124251; MGC124252; p450; p450arom
Orthologs:
Homo sapiens (human) : CYP19A1 (cytochrome P450 family 19 subfamily A member 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cyp19a1 (cytochrome P450, family 19, subfamily a, polypeptide 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102023780 (aromatase)
Pan paniscus (bonobo/pygmy chimpanzee) : CYP19A1 (cytochrome P450 family 19 subfamily A member 1)
Canis lupus familiaris (dog) : CYP19A1 (cytochrome P450 family 19 subfamily A member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101954950 (aromatase)
Sus scrofa (pig) : CYP19A2 (cytochrome P450 19A2)
Chlorocebus sabaeus (African green monkey) : CYP19A1 (cytochrome P450 family 19 subfamily A member 1)
Heterocephalus glaber (naked mole-rat) : LOC101702005 (aromatase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl954,165,937 - 54,268,110 (-)EnsemblGRCm38mm10GRCm38
GRCm38954,165,937 - 54,268,164 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37954,013,744 - 54,041,249 (-)NCBIGRCm37mm9NCBIm37
MGSCv36953,964,074 - 53,991,581 (-)NCBImm8
Celera951,408,025 - 51,435,376 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map929.49NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
 
More on Cyp19a1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737520
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-09-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.