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Gene: BGN (biglycan) Homo sapiens
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Symbol: BGN
Name: biglycan
Description: This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in bone growth, muscle development and regeneration, and collagen fibril assembly in multiple tissues. This protein may also regulate inflammation and innate immunity. Additionally, the encoded protein may contribute to atherosclerosis and aortic valve stenosis in human patients. This gene and the related gene decorin are thought to be the result of a gene duplication. [provided by RefSeq, Nov 2015]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: biglycan proteoglycan; bone/cartilage proteoglycan I; bone/cartilage proteoglycan-I; dermatan sulphate proteoglycan I; DSPG1; MRLS; PG-S1; PGI; SEMDX; SLRR1A; small leucine-rich protein 1A
Orthologs:
Mus musculus (house mouse) : Bgn (biglycan)  MGI  Alliance
Rattus norvegicus (Norway rat) : Bgn (biglycan)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bgn (biglycan)
Pan paniscus (bonobo/pygmy chimpanzee) : BGN (biglycan)
Canis lupus familiaris (dog) : BGN (biglycan)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bgn (biglycan)
Sus scrofa (pig) : BGN (biglycan)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X153,494,889 - 153,509,554 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X152,760,347 - 152,775,004 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X152,413,605 - 152,428,198 (+)NCBINCBI36hg18NCBI36
Build 34X152,281,257 - 152,295,851NCBI
CeleraX152,994,048 - 153,008,701 (+)NCBI
Cytogenetic MapXq28NCBI
HuRefX141,428,414 - 141,433,357 (+)NCBIHuRef
CHM1_1X152,634,856 - 152,649,519 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on BGN
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737524
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.