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Gene: Capn2 (calpain 2) Mus musculus
Symbol: Capn2
Name: calpain 2
Description: Exhibits calcium-dependent cysteine-type endopeptidase activity. Involved in several processes, including blastocyst development; cellular response to amino acid stimulus; and myoblast fusion. Localizes to several cellular components, including the chromatin; cytosol; and lysosome. Predicted to colocalize with the mitochondrial intermembrane space. Is expressed in several structures, including hindbrain; lens epithelium; oral region epithelium; skin; and spinal cord floor plate. Orthologous to human CAPN2 (calpain 2); PARTICIPATES IN the proteolytic pathway involving calcium-dependent proteases; Alzheimer's disease pathway; apoptotic cell death pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-di-tert-butyl-4-methylphenol; 4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 80 kDa M-calpain subunit; AI326419; calcium-activated neutral proteinase 2; CALP80; calpain M-type; calpain-2 catalytic subunit; calpain-2 large subunit; CANP 2; Capa-2; Capa2; cysteine proteinase; m-calpain; m-calpain 80 kDa large subunit; m-calpain large subunit; m-calpin; millimolar-calpain
Homo sapiens (human) : CAPN2 (calpain 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Capn2 (calpain 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Capn2 (calpain 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CAPN2 (calpain 2)
Canis lupus familiaris (dog) : CAPN2 (calpain 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Capn2 (calpain 2)
Sus scrofa (pig) : CAPN2 (calpain 2)
Chlorocebus sabaeus (green monkey) : CAPN2 (calpain 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1182,467,260 - 182,517,608 (-)Ensembl
GRCm381182,467,253 - 182,517,610 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371184,397,390 - 184,447,614 (-)NCBIGRCm37mm9NCBIm37
MGSCv361184,303,935 - 184,354,199 (-)NCBImm8
Celera1189,509,702 - 189,560,154 (-)NCBICelera
Cytogenetic Map1 H5NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Capn2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737526
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.