Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: APOA4 (apolipoprotein A4) Homo sapiens
Symbol: APOA4
Name: apolipoprotein A4
Description: Exhibits several functions, including cation binding activity; cholesterol transfer activity; and phosphatidylcholine-sterol O-acyltransferase activator activity. Involved in several processes, including cholesterol homeostasis; lipid transport; and positive regulation of lipid metabolic process. Localizes to chylomicron; high-density lipoprotein particle; and very-low-density lipoprotein particle. Colocalizes with cell surface. Implicated in Alzheimer's disease; colitis; myocardial infarction; and ulcerative colitis. Biomarker of several diseases, including Huntington's disease; Leber hereditary optic neuropathy; autoimmune disease of the nervous system (multiple); eye disease (multiple); and intermediate coronary syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: apo-AIV; apoA-IV; apolipoprotein A-IV; MGC142154; MGC142156
Mus musculus (house mouse) : Apoa4 (apolipoprotein A-IV)  MGI  Alliance
Rattus norvegicus (Norway rat) : Apoa4 (apolipoprotein A4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Apoa4 (apolipoprotein A4)
Pan paniscus (bonobo/pygmy chimpanzee) : APOA4 (apolipoprotein A4)
Canis lupus familiaris (dog) : APOA4 (apolipoprotein A4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Apoa4 (apolipoprotein A4)
Sus scrofa (pig) : APOA4 (apolipoprotein A4)
Chlorocebus sabaeus (African green monkey) : APOA4 (apolipoprotein A4)
Heterocephalus glaber (naked mole-rat) : Apoa4 (apolipoprotein A4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl11116,820,700 - 116,823,304 (-)EnsemblGRCh38hg38GRCh38
GRCh3811116,820,700 - 116,823,304 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711116,691,418 - 116,694,011 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611116,196,628 - 116,199,221 (-)NCBINCBI36hg18NCBI36
Build 3411116,196,628 - 116,199,162NCBI
Celera11113,849,234 - 113,851,827 (-)NCBI
Cytogenetic Map11q23.3NCBI
HuRef11112,623,690 - 112,626,283 (-)NCBIHuRef
CHM1_111116,576,178 - 116,578,767 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on APOA4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737553
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.