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Gene: HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2) Homo sapiens
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Symbol: HMGCS2
Name: 3-hydroxy-3-methylglutaryl-CoA synthase 2
CRRD ID: 737571
Description: Exhibits hydroxymethylglutaryl-CoA synthase activity and identical protein binding activity. Involved in acetyl-CoA metabolic process and ketone body biosynthetic process. Localizes to mitochondrion. Biomarker of hepatocellular carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 3-hydroxy-3-methylglutaryl coenzyme A synthase; 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial); 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial); HMG-CoA synthase; hydroxymethylglutaryl-CoA synthase, mitochondrial; mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase; testicular tissue protein Li 88
Orthologs:
Mus musculus (house mouse) : Hmgcs2 (3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hmgcs2 (3-hydroxy-3-methylglutaryl-CoA synthase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hmgcs2 (3-hydroxy-3-methylglutaryl-CoA synthase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2)
Canis lupus familiaris (dog) : HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hmgcs2 (3-hydroxy-3-methylglutaryl-CoA synthase 2)
Sus scrofa (pig) : LOC110260333 (hydroxymethylglutaryl-CoA synthase, mitochondrial-like)
Chlorocebus sabaeus (African green monkey) : HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2)
Heterocephalus glaber (naked mole-rat) : Hmgcs2 (3-hydroxy-3-methylglutaryl-CoA synthase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1119,748,002 - 119,768,905 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1119,747,996 - 119,768,905 (-)EnsemblGRCh38hg38GRCh38
GRCh381119,747,996 - 119,768,932 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371120,290,619 - 120,311,555 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361120,092,525 - 120,113,041 (-)NCBINCBI36hg18NCBI36
Build 341120,003,046 - 120,023,560NCBI
Celera1118,521,355 - 118,542,283 (-)NCBI
Cytogenetic Map1p12NCBI
HuRef1118,149,159 - 118,170,093 (-)NCBIHuRef
CHM1_11120,406,161 - 120,427,088 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on HMGCS2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737571
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.