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Gene: RAF1 (Raf-1 proto-oncogene, serine/threonine kinase) Homo sapiens
Symbol: RAF1
Name: Raf-1 proto-oncogene, serine/threonine kinase
Description: Exhibits enzyme binding activity; identical protein binding activity; and protein serine/threonine kinase activity. Involved in several processes, including activation of adenylate cyclase activity; negative regulation of protein complex assembly; and positive regulation of protein phosphorylation. Localizes to several cellular components, including the Golgi apparatus; cytosol; and nuclear speck. Implicated in LEOPARD syndrome 2; Noonan syndrome (multiple); adenocarcinoma (multiple); and dilated cardiomyopathy 1NN. Biomarker of colorectal adenocarcinoma; colorectal adenoma; and prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: c-Raf; C-Raf proto-oncogene, serine/threonine kinase; CMD1NN; CRAF; murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-msv); NS5; Oncogene RAF1; proto-oncogene c-RAF; raf proto-oncogene serine/threonine protein kinase; RAF proto-oncogene serine/threonine-protein kinase; Raf-1; v-raf-1 murine leukemia viral oncogene homolog 1; v-raf-1 murine leukemia viral oncogene-like protein 1
Mus musculus (house mouse) : Raf1 (v-raf-leukemia viral oncogene 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Raf1 (Raf-1 proto-oncogene, serine/threonine kinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Raf1 (Raf-1 proto-oncogene, serine/threonine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : RAF1 (Raf-1 proto-oncogene, serine/threonine kinase)
Canis lupus familiaris (dog) : RAF1 (Raf-1 proto-oncogene, serine/threonine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Raf1 (Raf-1 proto-oncogene, serine/threonine kinase)
Sus scrofa (pig) : RAF1 (Raf-1 proto-oncogene, serine/threonine kinase)
more info ...
Related Pseudogenes: RAF1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38312,583,601 - 12,664,201 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37312,625,100 - 12,705,700 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36312,600,108 - 12,680,678 (-)NCBINCBI36hg18NCBI36
Build 34312,600,107 - 12,680,678NCBI
Celera312,563,426 - 12,643,994 (-)NCBI
Cytogenetic Map3p25.2NCBI
HuRef312,559,317 - 12,640,382 (-)NCBIHuRef
CHM1_1312,575,179 - 12,655,743 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants