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Gene: IL2RB (interleukin 2 receptor subunit beta) Homo sapiens
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Symbol: IL2RB
Name: interleukin 2 receptor subunit beta
Description: Exhibits interleukin-15 receptor activity; interleukin-2 binding activity; and interleukin-2 receptor activity. Involved in interleukin-15-mediated signaling pathway; negative regulation of apoptotic process; and positive regulation of phagocytosis. Localizes to the cell surface. Implicated in asthma; myasthenia gravis; and primary immunodeficiency disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD122; CD122 antigen; high affinity IL-2 receptor beta subunit; high affinity IL-2 receptor subunit beta; IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; IL15RB; IMD63; interleukin 15 receptor, beta; interleukin 2 receptor, beta; interleukin 2 receptor, beta chain; interleukin-15 receptor subunit beta; interleukin-2 receptor subunit beta; P70-75; p75
Orthologs:
Mus musculus (house mouse) : Il2rb (interleukin 2 receptor, beta chain)  MGI  Alliance
Rattus norvegicus (Norway rat) : Il2rb (interleukin 2 receptor subunit beta)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il2rb (interleukin 2 receptor subunit beta)
Pan paniscus (bonobo/pygmy chimpanzee) : IL2RB (interleukin 2 receptor subunit beta)
Canis lupus familiaris (dog) : IL2RB (interleukin 2 receptor subunit beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il2rb (interleukin 2 receptor subunit beta)
Sus scrofa (pig) : IL2RB (interleukin 2 receptor subunit beta)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382237,125,838 - 37,175,118 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372237,521,878 - 37,552,414 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362235,851,824 - 35,875,908 (-)NCBINCBI36hg18NCBI36
Build 342235,846,381 - 35,870,462NCBI
Celera2221,322,955 - 21,347,014 (-)NCBI
Cytogenetic Map22q12.3NCBI
HuRef2220,486,973 - 20,511,039 (-)NCBIHuRef
CHM1_12237,481,108 - 37,505,190 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on IL2RB
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737611
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.