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Gene: IL2RB (interleukin 2 receptor subunit beta) Homo sapiens
Symbol: IL2RB
Name: interleukin 2 receptor subunit beta
Description: Exhibits interleukin-15 receptor activity; interleukin-2 binding activity; and interleukin-2 receptor activity. Involved in interleukin-15-mediated signaling pathway; negative regulation of apoptotic process; and positive regulation of phagocytosis. Localizes to the cell surface. Implicated in asthma; myasthenia gravis; and primary immunodeficiency disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD122; CD122 antigen; high affinity IL-2 receptor beta subunit; high affinity IL-2 receptor subunit beta; IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; IL15RB; IMD63; interleukin 15 receptor, beta; interleukin 2 receptor, beta; interleukin 2 receptor, beta chain; interleukin-15 receptor subunit beta; interleukin-2 receptor subunit beta; P70-75; p75
Mus musculus (house mouse) : Il2rb (interleukin 2 receptor, beta chain)  MGI  Alliance
Rattus norvegicus (Norway rat) : Il2rb (interleukin 2 receptor subunit beta)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il2rb (interleukin 2 receptor subunit beta)
Pan paniscus (bonobo/pygmy chimpanzee) : IL2RB (interleukin 2 receptor subunit beta)
Canis lupus familiaris (dog) : IL2RB (interleukin 2 receptor subunit beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il2rb (interleukin 2 receptor subunit beta)
Sus scrofa (pig) : IL2RB (interleukin 2 receptor subunit beta)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382237,125,838 - 37,175,118 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372237,521,878 - 37,552,414 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362235,851,824 - 35,875,908 (-)NCBINCBI36hg18NCBI36
Build 342235,846,381 - 35,870,462NCBI
Celera2221,322,955 - 21,347,014 (-)NCBI
Cytogenetic Map22q12.3NCBI
HuRef2220,486,973 - 20,511,039 (-)NCBIHuRef
CHM1_12237,481,108 - 37,505,190 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on IL2RB
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737611
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.