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Gene: GPC3 (glypican 3) Homo sapiens
Symbol: GPC3
Name: glypican 3
Description: Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DGSX; glypican proteoglycan 3; glypican-3; GTR2-2; heparan sulphate proteoglycan; intestinal protein OCI-5; MXR7; OCI-5; SDYS; secreted glypican-3; SGB; SGBS; SGBS1
Mus musculus (house mouse) : Gpc3 (glypican 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gpc3 (glypican 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gpc3 (glypican 3)
Pan paniscus (bonobo/pygmy chimpanzee) : GPC3 (glypican 3)
Canis lupus familiaris (dog) : GPC3 (glypican 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gpc3 (glypican 3)
Sus scrofa (pig) : GPC3 (glypican 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X133,535,745 - 133,985,646 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X132,669,773 - 133,119,673 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X132,497,439 - 132,947,332 (-)NCBINCBI36hg18NCBI36
Build 34X132,395,297 - 132,845,186NCBI
CeleraX133,056,670 - 133,506,461 (-)NCBI
Cytogenetic MapXq26.2NCBI
HuRefX122,070,349 - 122,518,471 (-)NCBIHuRef
CHM1_1X132,581,479 - 133,031,377 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on GPC3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737615
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-07-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.