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Gene: Kmt2b (lysine methyltransferase 2B) Rattus norvegicus
Symbol: Kmt2b
Name: lysine methyltransferase 2B
Description: Predicted to have histone methyltransferase activity (H3-K4 specific); unmethylated CpG binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including female gamete generation; histone H3-K4 methylation; and regulation of gene expression. Predicted to localize to histone methyltransferase complex. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma; dystonia; and hepatocellular carcinoma. Orthologous to human KMT2B (lysine methyltransferase 2B); PARTICIPATES IN histone modification pathway; INTERACTS WITH bisphenol A; glyphosate; 17beta-estradiol (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Also known as: histone-lysine N-methyltransferase 2B-like; LOC102550344; LOC361543; LOW QUALITY PROTEIN: histone-lysine N-methyltransferase 2B; lysine (K)-specific methyltransferase 2B; Mll4; myeloid/lymphoid or mixed-lineage leukemia 4; RGD1308331; similar to Trithorax homolog 2 (Mixed lineage leukemia gene homolog 2 protein); Wbp7; WW domain binding protein 7
Homo sapiens (human) : KMT2B (lysine methyltransferase 2B)  HGNC  Alliance
Mus musculus (house mouse) : Kmt2b (lysine (K)-specific methyltransferase 2B)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kmt2b (lysine methyltransferase 2B)
Pan paniscus (bonobo/pygmy chimpanzee) : KMT2B (lysine methyltransferase 2B)
Canis lupus familiaris (dog) : KMT2B (lysine methyltransferase 2B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kmt2b (lysine methyltransferase 2B)
Sus scrofa (pig) : KMT2B (lysine methyltransferase 2B)
Chlorocebus sabaeus (African green monkey) : KMT2B (lysine methyltransferase 2B)
Heterocephalus glaber (naked mole-rat) : Kmt2b (lysine methyltransferase 2B)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0189,022,889 - 89,042,176 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl189,023,200 - 89,042,176 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0190,177,704 - 90,197,879 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4185,613,847 - 85,633,136 (-)NCBIRGSC3.4rn4RGSC3.4
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Kmt2b
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 7678027
Created: 2013-12-18
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.