Havcr2 (hepatitis A virus cellular receptor 2) - Chinchilla Research Resource Database
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Gene: Havcr2 (hepatitis A virus cellular receptor 2) Chinchilla lanigera
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Symbol: Havcr2
Name: hepatitis A virus cellular receptor 2
CRRD ID: 8799895
Description: INVOLVED IN cellular response to lipopolysaccharide (ortholog); defense response to Gram-positive bacterium (ortholog); macrophage activation involved in immune response (ortholog); ASSOCIATED WITH asthma (ortholog); cystic fibrosis (ortholog); Eczema (ortholog); FOUND IN cell surface (ortholog); early endosome (ortholog); immunological synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Orthologs:
Homo sapiens (human) : HAVCR2 (hepatitis A virus cellular receptor 2)  HGNC  Alliance
Mus musculus (house mouse) : Havcr2 (hepatitis A virus cellular receptor 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Havcr2 (hepatitis A virus cellular receptor 2)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : HAVCR2 (hepatitis A virus cellular receptor 2)
Canis lupus familiaris (dog) : HAVCR2 (hepatitis A virus cellular receptor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Havcr2 (hepatitis A virus cellular receptor 2)
Sus scrofa (pig) : HAVCR2 (hepatitis A virus cellular receptor 2)
Chlorocebus sabaeus (African green monkey) : HAVCR2 (hepatitis A virus cellular receptor 2)
Heterocephalus glaber (naked mole-rat) : Havcr2 (hepatitis A virus cellular receptor 2)
more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540811,291,937 - 11,311,320 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540811,289,920 - 11,311,216 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to lipopolysaccharide  (ISO)
defense response to Gram-positive bacterium  (ISO)
macrophage activation involved in immune response  (ISO)
maternal process involved in female pregnancy  (ISO)
natural killer cell tolerance induction  (ISO)
negative regulation of defense response to bacterium  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of granulocyte colony-stimulating factor production  (ISO)
negative regulation of immune response to tumor cell  (ISO)
negative regulation of immunological synapse formation  (ISO)
negative regulation of innate immune response  (ISO)
negative regulation of interferon-alpha production  (ISO)
negative regulation of interferon-gamma production  (ISO)
negative regulation of interleukin-2 production  (ISO)
negative regulation of interleukin-3 production  (ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of myeloid dendritic cell activation  (ISO)
negative regulation of natural killer cell activation  (ISO)
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target  (ISO)
negative regulation of NF-kappaB transcription factor activity  (ISO)
negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell  (ISO)
negative regulation of T cell proliferation  (ISO)
negative regulation of T-helper 1 type immune response  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of type I interferon production  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of defense response to bacterium  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of innate immune response  (ISO)
positive regulation of interferon-gamma production  (ISO)
positive regulation of interleukin-1 production  (ISO)
positive regulation of interleukin-4 production  (ISO)
positive regulation of macrophage activation  (ISO)
positive regulation of NIK/NF-kappaB signaling  (ISO)
positive regulation of T cell proliferation  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
regulation of tolerance induction dependent upon immune response  (ISO)
toll-like receptor 3 signaling pathway  (ISO)
toll-like receptor 7 signaling pathway  (ISO)
toll-like receptor 9 signaling pathway  (ISO)

Cellular Component

Molecular Function

References


Genomics

Comparative Map Data
Havcr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540811,291,937 - 11,311,320 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540811,289,920 - 11,311,216 (-)NCBIChiLan1.0ChiLan1.0
HAVCR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5157,085,832 - 157,142,869 (-)EnsemblGRCh38hg38GRCh38
GRCh385157,085,832 - 157,109,044 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375156,512,843 - 156,536,248 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365156,445,421 - 156,468,716 (-)NCBINCBI36hg18NCBI36
Build 345156,445,420 - 156,468,716NCBI
Celera5152,539,374 - 152,562,664 (-)NCBI
Cytogenetic Map5q33.3NCBI
HuRef5151,601,069 - 151,624,237 (-)NCBIHuRef
CHM1_15155,945,610 - 155,968,997 (-)NCBICHM1_1
Havcr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391146,345,758 - 46,372,082 (+)NCBI
GRCm381146,454,931 - 46,481,255 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1146,454,935 - 46,481,255 (+)EnsemblGRCm38mm10GRCm38
MGSCv371146,268,433 - 46,294,757 (+)NCBIGRCm37mm9NCBIm37
MGSCv361146,298,358 - 46,324,678 (+)NCBImm8
Celera1151,038,900 - 51,067,047 (+)NCBICelera
Cytogenetic Map11B1.1NCBI
Havcr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01031,561,838 - 31,590,624 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1031,561,895 - 31,588,943 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01031,376,989 - 31,404,231 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41031,585,703 - 31,610,825 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11031,579,175 - 31,610,030 (+)NCBI
Celera1030,333,452 - 30,358,912 (+)NCBICelera
Cytogenetic Map10q21NCBI
HAVCR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15159,107,938 - 159,134,973 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5159,108,915 - 159,131,007 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05152,486,125 - 152,514,004 (-)NCBIMhudiblu_PPA_v0panPan3
HAVCR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl453,012,234 - 53,033,393 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1453,018,990 - 53,032,035 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Havcr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365156,001,324 - 6,015,407 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HAVCR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1666,139,535 - 66,160,562 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11666,138,157 - 66,160,568 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21671,988,583 - 72,008,100 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HAVCR2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl2359,475,826 - 59,500,836 (-)Ensembl
ChlSab1.12359,479,794 - 59,501,532 (-)NCBI
Havcr2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473332,521,318 - 32,527,499 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000023716   ⟹   ENSCLAP00000023494
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540811,291,937 - 11,311,320 (-)Ensembl
RefSeq Acc Id: XM_005376221   ⟹   XP_005376278
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540811,289,920 - 11,311,205 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005376222   ⟹   XP_005376279
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540811,294,817 - 11,311,216 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005376278 (Get FASTA)   NCBI Sequence Viewer  
  XP_005376279 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005376278   ⟸   XM_005376221
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005376279   ⟸   XM_005376222
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCLAP00000023494   ⟸   ENSCLAT00000023716


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000016115 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000023494 ENTREZGENE
Ensembl Transcript ENSCLAT00000023716 ENTREZGENE
NCBI Gene Havcr2 ENTREZGENE