Hnf4a (hepatocyte nuclear factor 4 alpha) - Chinchilla Research Resource Database
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Gene: Hnf4a (hepatocyte nuclear factor 4 alpha) Chinchilla lanigera
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Symbol: Hnf4a
Name: hepatocyte nuclear factor 4 alpha
CRRD ID: 8897372
Description: ENCODES a protein that exhibits arachidonic acid binding (ortholog); chromatin binding (ortholog); cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN acyl-CoA metabolic process (ortholog); aging (ortholog); blood coagulation (ortholog); PARTICIPATES IN forkhead class A signaling pathway; hypoxia inducible factor pathway; ASSOCIATED WITH Congenital Hyperinsulinism (ortholog); Developmental Disabilities (ortholog); diabetes mellitus (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: hepatocyte nuclear factor 4, alpha; hepatocyte nuclear factor 4-alpha
Orthologs:
Homo sapiens (human) : HNF4A (hepatocyte nuclear factor 4 alpha)  HGNC  Alliance
Mus musculus (house mouse) : Hnf4a (hepatic nuclear factor 4, alpha)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hnf4a (hepatocyte nuclear factor 4, alpha)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : HNF4A (hepatocyte nuclear factor 4 alpha)
Canis lupus familiaris (dog) : HNF4A (hepatocyte nuclear factor 4 alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hnf4a (hepatocyte nuclear factor 4 alpha)
Sus scrofa (pig) : HNF4A (hepatocyte nuclear factor 4 alpha)
Chlorocebus sabaeus (African green monkey) : HNF4A (hepatocyte nuclear factor 4 alpha)
Heterocephalus glaber (naked mole-rat) : Hnf4a (hepatocyte nuclear factor 4 alpha)
more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544512,924,662 - 12,984,281 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544512,925,248 - 12,962,501 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acyl-CoA metabolic process  (ISO)
aging  (ISO)
blood coagulation  (ISO)
cell differentiation  (ISO)
cell-cell junction organization  (ISO)
cellular response to hypoxia  (ISO)
cholesterol homeostasis  (ISO)
establishment of tissue polarity  (ISO)
glucose homeostasis  (ISO)
hepatocyte differentiation  (ISO)
lipid homeostasis  (ISO)
lipid metabolic process  (ISO)
negative regulation of activation of Janus kinase activity  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of mitotic cell cycle  (ISO)
negative regulation of protein import into nucleus  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
negative regulation of tyrosine phosphorylation of STAT protein  (ISO)
ornithine metabolic process  (ISO)
phospholipid homeostasis  (ISO)
positive regulation of fatty acid biosynthetic process  (ISO)
positive regulation of gluconeogenesis  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
regulation of circadian rhythm  (ISO)
regulation of gastrulation  (ISO)
regulation of insulin secretion  (ISO)
regulation of lipid metabolic process  (ISO)
regulation of microvillus assembly  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation of transcription, DNA-templated  (ISO)
response to cAMP  (ISO)
response to dexamethasone  (ISO)
response to drug  (ISO)
response to glucose  (ISO)
response to lipopolysaccharide  (ISO)
response to nutrient levels  (ISO)
sex differentiation  (ISO)
signal transduction involved in regulation of gene expression  (ISO)
SMAD protein signal transduction  (ISO)
triglyceride homeostasis  (ISO)
xenobiotic metabolic process  (ISO)

Cellular Component
cytoplasm  (ISO)
nucleoplasm  (ISO)
nucleus  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References


Genomics

Comparative Map Data
Hnf4a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544512,924,662 - 12,984,281 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544512,925,248 - 12,962,501 (-)NCBIChiLan1.0ChiLan1.0
HNF4A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2044,355,700 - 44,434,596 (+)EnsemblGRCh38hg38GRCh38
GRCh382044,355,699 - 44,434,596 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372042,984,441 - 43,061,485 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362042,417,855 - 42,493,444 (+)NCBINCBI36hg18NCBI36
Build 342042,463,337 - 42,486,690NCBI
Celera2039,693,092 - 39,768,681 (+)NCBI
Cytogenetic Map20q13.12NCBI
HuRef2039,720,990 - 39,802,805 (+)NCBIHuRef
CHM1_12042,886,684 - 42,964,390 (+)NCBICHM1_1
Hnf4a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392163,348,731 - 163,414,827 (+)NCBI
GRCm382163,506,811 - 163,572,907 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2163,506,808 - 163,572,910 (+)EnsemblGRCm38mm10GRCm38
MGSCv372163,372,924 - 163,398,643 (+)NCBIGRCm37mm9NCBIm37
MGSCv362163,238,629 - 163,264,348 (+)NCBImm8
Celera2169,490,574 - 169,516,277 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map284.32NCBI
Hnf4a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.03159,902,441 - 159,965,003 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3159,902,441 - 159,965,003 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03166,093,091 - 166,155,667 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43154,459,863 - 154,482,825 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13154,365,898 - 154,388,861 (+)NCBI
Celera3150,839,856 - 150,901,426 (+)NCBICelera
Cytogenetic Map3q42NCBI
RH 3.4 Map31376.5RGD
HNF4A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12041,823,939 - 41,856,536 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2041,779,034 - 41,856,536 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02040,684,450 - 40,763,824 (+)NCBI
HNF4A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2431,847,961 - 31,905,916 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12431,847,864 - 31,908,337 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Hnf4a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365302,401,053 - 2,425,989 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HNF4A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1746,783,777 - 46,847,503 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11746,783,772 - 46,847,505 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21752,232,425 - 52,296,703 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HNF4A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl219,388,891 - 19,421,664 (-)Ensembl
ChlSab1.1219,390,870 - 19,466,300 (-)NCBI
Hnf4a
(Heterocephalus glaber - naked mole-rat)
No map positions available.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000023831   ⟹   ENSCLAP00000023607
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495544512,924,662 - 12,951,351 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000023832   ⟹   ENSCLAP00000023608
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495544512,946,158 - 12,984,281 (-)Ensembl
RefSeq Acc Id: XM_005392474   ⟹   XP_005392531
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544512,925,248 - 12,962,497 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005392475   ⟹   XP_005392532
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544512,925,248 - 12,962,501 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005392477   ⟹   XP_005392534
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544512,925,248 - 12,951,351 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005392478   ⟹   XP_005392535
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544512,925,248 - 12,951,351 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005392479   ⟹   XP_005392536
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544512,925,248 - 12,951,930 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005392531   ⟸   XM_005392474
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005392532   ⟸   XM_005392475
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005392536   ⟸   XM_005392479
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_005392535   ⟸   XM_005392478
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_005392534   ⟸   XM_005392477
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSCLAP00000023608   ⟸   ENSCLAT00000023832
RefSeq Acc Id: ENSCLAP00000023607   ⟸   ENSCLAT00000023831


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000016192 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000023607 ENTREZGENE
Ensembl Transcript ENSCLAT00000023831 ENTREZGENE
NCBI Gene Hnf4a ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Hnf4a  hepatocyte nuclear factor 4 alpha    hepatocyte nuclear factor 4, alpha  Symbol and/or name change 5135510 APPROVED

 



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.