Sirt2 (sirtuin 2) - Chinchilla Research Resource Database
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Gene: Sirt2 (sirtuin 2) Chinchilla lanigera
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Symbol: Sirt2
Name: sirtuin 2
CRRD ID: 8963181
Description: ENCODES a protein that exhibits beta-tubulin binding (ortholog); chromatin binding (ortholog); histone acetyltransferase binding (ortholog); INVOLVED IN cellular lipid catabolic process (ortholog); cellular response to caloric restriction (ortholog); cellular response to epinephrine stimulus (ortholog); PARTICIPATES IN histone modification pathway; Sirtuin mediated pathway; ASSOCIATED WITH intermittent claudication (ortholog); malignant glioma (ortholog); non-alcoholic fatty liver disease (ortholog); FOUND IN centriole (ortholog); centrosome (ortholog); chromosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: NAD-dependent protein deacetylase sirtuin-2
Orthologs:
Homo sapiens (human) : SIRT2 (sirtuin 2)  HGNC  Alliance
Mus musculus (house mouse) : Sirt2 (sirtuin 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sirt2 (sirtuin 2)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : SIRT2 (sirtuin 2)
Canis lupus familiaris (dog) : SIRT2 (sirtuin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sirt2 (sirtuin 2)
Sus scrofa (pig) : SIRT2 (sirtuin 2)
Chlorocebus sabaeus (African green monkey) : SIRT2 (sirtuin 2)
Heterocephalus glaber (naked mole-rat) : Sirt2 (sirtuin 2)
more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955468626,365 - 644,441 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955468626,365 - 644,441 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular lipid catabolic process  (ISO)
cellular response to caloric restriction  (ISO)
cellular response to epinephrine stimulus  (ISO)
cellular response to hepatocyte growth factor stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to molecule of bacterial origin  (ISO)
cellular response to oxidative stress  (ISO)
central nervous system development  (ISO)
hepatocyte growth factor receptor signaling pathway  (ISO)
histone deacetylation  (ISO)
histone H3 deacetylation  (ISO)
histone H4 deacetylation  (ISO)
myelination in peripheral nervous system  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of autophagy  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of defense response to bacterium  (ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of NLRP3 inflammasome complex assembly  (ISO)
negative regulation of oligodendrocyte differentiation  (ISO)
negative regulation of oligodendrocyte progenitor proliferation  (ISO)
negative regulation of peptidyl-threonine phosphorylation  (ISO)
negative regulation of protein catabolic process  (ISO)
negative regulation of reactive oxygen species metabolic process  (ISO)
negative regulation of striated muscle tissue development  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription from RNA polymerase II promoter in response to hypoxia  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
peptidyl-lysine deacetylation  (ISO)
phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of attachment of spindle microtubules to kinetochore  (ISO)
positive regulation of cell division  (ISO)
positive regulation of DNA binding  (ISO)
positive regulation of execution phase of apoptosis  (ISO)
positive regulation of meiotic nuclear division  (ISO)
positive regulation of oocyte maturation  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (ISO)
protein ADP-ribosylation  (ISO)
protein deacetylation  (ISO)
protein kinase B signaling  (ISO)
regulation of cell cycle  (ISO)
regulation of fat cell differentiation  (ISO)
regulation of myelination  (ISO)
regulation of postsynaptic neurotransmitter receptor internalization  (ISO)
substantia nigra development  (ISO)
tubulin deacetylation  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References


Genomics

Comparative Map Data
Sirt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955468626,365 - 644,441 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955468626,365 - 644,441 (+)NCBIChiLan1.0ChiLan1.0
SIRT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1938,878,555 - 38,899,862 (-)EnsemblGRCh38hg38GRCh38
GRCh381938,878,555 - 38,899,733 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371939,369,195 - 39,390,502 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361944,061,040 - 44,082,201 (-)NCBINCBI36hg18NCBI36
Build 341944,061,039 - 44,082,193NCBI
Celera1936,171,632 - 36,192,939 (-)NCBI
Cytogenetic Map19q13.2NCBI
HuRef1935,815,856 - 35,837,294 (-)NCBIHuRef
CHM1_11939,369,665 - 39,390,970 (-)NCBICHM1_1
Sirt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,466,177 - 28,488,090 (+)NCBI
GRCm38728,766,752 - 28,788,665 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,766,735 - 28,788,661 (+)EnsemblGRCm38mm10GRCm38
MGSCv37729,551,771 - 29,573,684 (+)NCBIGRCm37mm9NCBIm37
MGSCv36728,475,543 - 28,497,420 (+)NCBImm8
Celera723,327,529 - 23,349,457 (+)NCBICelera
Cytogenetic Map7B1NCBI
Sirt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0186,948,866 - 86,971,954 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl186,948,918 - 86,971,952 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0188,130,012 - 88,153,086 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,873,578 - 83,896,121 (+)NCBIRGSC3.4rn4RGSC3.4
Celera178,446,589 - 78,469,133 (+)NCBICelera
Cytogenetic Map1q21NCBI
SIRT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11944,533,965 - 44,554,838 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1944,533,965 - 44,554,799 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01935,984,453 - 36,005,582 (-)NCBIMhudiblu_PPA_v0panPan3
SIRT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1114,224,900 - 114,234,583 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11114,224,922 - 114,235,041 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Sirt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366611,828,868 - 1,849,892 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIRT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl647,682,424 - 47,703,529 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1647,682,427 - 47,703,408 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2643,218,298 - 43,228,967 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SIRT2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl633,493,079 - 33,518,647 (-)Ensembl
ChlSab1.1633,493,106 - 33,518,793 (-)NCBI
Sirt2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479412,239,363 - 12,259,561 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000019963   ⟹   ENSCLAP00000019770
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955468626,365 - 644,441 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000019964   ⟹   ENSCLAP00000019771
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955468626,460 - 643,884 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000019965   ⟹   ENSCLAP00000019772
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955468628,415 - 644,441 (+)Ensembl
RefSeq Acc Id: XM_005399813   ⟹   XP_005399870
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955468628,415 - 644,441 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005399815   ⟹   XP_005399872
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955468628,416 - 644,441 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005399816   ⟹   XP_005399873
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955468629,332 - 644,441 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005399817   ⟹   XP_005399874
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955468626,365 - 644,441 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005399818   ⟹   XP_005399875
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955468626,368 - 644,441 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005399819   ⟹   XP_005399876
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955468626,525 - 644,441 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005399820   ⟹   XP_005399877
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955468629,588 - 644,441 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005399874   ⟸   XM_005399817
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_005399875   ⟸   XM_005399818
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_005399876   ⟸   XM_005399819
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_005399872   ⟸   XM_005399815
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005399870   ⟸   XM_005399813
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005399873   ⟸   XM_005399816
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_005399877   ⟸   XM_005399820
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSCLAP00000019772   ⟸   ENSCLAT00000019965
RefSeq Acc Id: ENSCLAP00000019771   ⟸   ENSCLAT00000019964
RefSeq Acc Id: ENSCLAP00000019770   ⟸   ENSCLAT00000019963


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000013560 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000019770 ENTREZGENE
  ENSCLAP00000019771 ENTREZGENE
  ENSCLAP00000019772 ENTREZGENE
Ensembl Transcript ENSCLAT00000019963 ENTREZGENE
  ENSCLAT00000019964 ENTREZGENE
  ENSCLAT00000019965 ENTREZGENE
NCBI Gene Sirt2 ENTREZGENE