Lrp5 (LDL receptor related protein 5) - Chinchilla Research Resource Database
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Gene: Lrp5 (LDL receptor related protein 5) Chinchilla lanigera
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Symbol: Lrp5
Name: LDL receptor related protein 5
CRRD ID: 9040848
Description: ENCODES a protein that exhibits coreceptor activity involved in Wnt signaling pathway (ortholog); Wnt-activated receptor activity (ortholog); Wnt-protein binding (ortholog); INVOLVED IN adipose tissue development (ortholog); anatomical structure regression (ortholog); anterior/posterior pattern specification (ortholog); PARTICIPATES IN altered Wnt signaling, canonical pathway; N-cadherin signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Arteriovenous Fistula (ortholog); autosomal dominant osteopetrosis 1 (ortholog); autosomal dominant polycystic kidney disease (ortholog); FOUND IN plasma membrane (ortholog); receptor complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: low density lipoprotein receptor-related protein 5; low-density lipoprotein receptor-related protein 5
Orthologs:
Homo sapiens (human) : LRP5 (LDL receptor related protein 5)  HGNC  Alliance
Mus musculus (house mouse) : Lrp5 (low density lipoprotein receptor-related protein 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Lrp5 (LDL receptor related protein 5)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : LRP5 (LDL receptor related protein 5)
Canis lupus familiaris (dog) : LRP5 (LDL receptor related protein 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lrp5 (LDL receptor related protein 5)
Sus scrofa (pig) : LRP5 (LDL receptor related protein 5)
Chlorocebus sabaeus (African green monkey) : LRP5 (LDL receptor related protein 5)
Heterocephalus glaber (naked mole-rat) : Lrp5 (LDL receptor related protein 5)
more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542217,394,371 - 17,505,763 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542217,394,371 - 17,475,244 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adipose tissue development  (ISO)
anatomical structure regression  (ISO)
anterior/posterior pattern specification  (ISO)
apoptotic process involved in blood vessel morphogenesis  (ISO)
bone development  (ISO)
bone marrow development  (ISO)
bone morphogenesis  (ISO)
bone remodeling  (ISO)
branching involved in mammary gland duct morphogenesis  (ISO)
canonical Wnt signaling pathway  (ISO)
cell migration involved in gastrulation  (ISO)
cell-cell signaling involved in mammary gland development  (ISO)
cholesterol homeostasis  (ISO)
cholesterol metabolic process  (ISO)
embryonic digit morphogenesis  (ISO)
extracellular matrix-cell signaling  (ISO)
gastrulation with mouth forming second  (ISO)
glucose catabolic process  (ISO)
limb morphogenesis  (ISO)
mammary gland duct morphogenesis  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of protein serine/threonine kinase activity  (ISO)
Norrin signaling pathway  (ISO)
osteoblast development  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of fat cell differentiation  (ISO)
positive regulation of mesenchymal cell proliferation  (ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of osteoblast proliferation  (ISO)
positive regulation of skeletal muscle acetylcholine-gated channel clustering  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
regulation of apoptotic process  (ISO)
regulation of blood pressure  (ISO)
regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
response to peptide hormone  (ISO)
response to radiation  (ISO)
retina morphogenesis in camera-type eye  (ISO)
retina vasculature morphogenesis in camera-type eye  (ISO)
retinal blood vessel morphogenesis  (ISO)
somatic stem cell population maintenance  (ISO)
vasculature development  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References


Genomics

Comparative Map Data
Lrp5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542217,394,371 - 17,505,763 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542217,394,371 - 17,475,244 (-)NCBIChiLan1.0ChiLan1.0
LRP5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1168,312,591 - 68,449,275 (+)EnsemblGRCh38hg38GRCh38
GRCh381168,298,866 - 68,449,275 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371168,080,077 - 68,216,743 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361167,836,684 - 67,973,319 (+)NCBINCBI36hg18NCBI36
Build 341167,836,710 - 67,973,317NCBI
Celera1165,414,949 - 65,552,023 (+)NCBI
Cytogenetic Map11q13.2NCBI
HuRef1164,450,891 - 64,552,653 (+)NCBIHuRef
CHM1_11167,964,539 - 68,100,925 (+)NCBICHM1_1
Lrp5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,634,825 - 3,736,574 (-)NCBI
GRCm38193,584,825 - 3,686,585 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,584,828 - 3,686,564 (-)EnsemblGRCm38mm10GRCm38
MGSCv37193,584,825 - 3,686,564 (-)NCBIGRCm37mm9NCBIm37
MGSCv36193,584,869 - 3,686,554 (-)NCBImm8
Celera193,456,985 - 3,596,074 (-)NCBICelera
Cytogenetic Map19ANCBI
Lrp5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01218,816,833 - 218,920,147 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1218,816,841 - 218,920,094 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01225,689,353 - 225,793,075 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41206,102,750 - 206,206,350 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11206,256,235 - 206,359,808 (-)NCBI
Celera1198,369,819 - 198,473,093 (-)NCBICelera
Cytogenetic Map1q42-q43NCBI
LRP5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11166,794,645 - 66,840,019 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1166,735,246 - 66,839,817 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01163,396,511 - 63,534,471 (+)NCBIMhudiblu_PPA_v0panPan3
LRP5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1849,439,483 - 49,516,396 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11849,439,494 - 49,555,375 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Lrp5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365991,746,309 - 1,814,471 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRP5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl24,533,593 - 4,653,945 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.124,533,721 - 4,653,997 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.223,168,598 - 3,216,170 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRP5
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl16,089,930 - 6,190,383 (-)Ensembl
ChlSab1.116,090,048 - 6,224,956 (-)NCBI
Lrp5
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476718,438,165 - 18,551,362 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000023916   ⟹   ENSCLAP00000023690
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542217,394,371 - 17,505,763 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000023917   ⟹   ENSCLAP00000023691
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542217,394,575 - 17,475,590 (-)Ensembl
RefSeq Acc Id: XM_013514225   ⟹   XP_013369679
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542217,394,371 - 17,475,244 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013514226   ⟹   XP_013369680
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542217,394,371 - 17,475,244 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013369679 (Get FASTA)   NCBI Sequence Viewer  
  XP_013369680 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013369680   ⟸   XM_013514226
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013369679   ⟸   XM_013514225
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCLAP00000023690   ⟸   ENSCLAT00000023916
RefSeq Acc Id: ENSCLAP00000023691   ⟸   ENSCLAT00000023917


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000016254 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000023690 ENTREZGENE
Ensembl Transcript ENSCLAT00000023916 ENTREZGENE
NCBI Gene Lrp5 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Lrp5  LDL receptor related protein 5    low density lipoprotein receptor-related protein 5  Symbol and/or name change 5135510 APPROVED