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The mechanism of eukaryotic translation initiation: new insights and challenges.

Authors: Hinnebusch, AG  Lorsch, JR 
Citation: Hinnebusch AG and Lorsch JR, Cold Spring Harb Perspect Biol. 2012 Oct 1;4(10). pii: a011544. doi: 10.1101/cshperspect.a011544.
Pubmed: (View Article at PubMed) PMID:22815232
DOI: Full-text: DOI:10.1101/cshperspect.a011544

Translation initiation in eukaryotes is a highly regulated and complex stage of gene expression. It requires the action of at least 12 initiation factors, many of which are known to be the targets of regulatory pathways. Here we review our current understanding of the molecular mechanics of eukaryotic translation initiation, focusing on recent breakthroughs from in vitro and in vivo studies. We also identify important unanswered questions that will require new ideas and techniques to solve.


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CRRD Object Information
CRRD ID: 10044017
Created: 2015-06-01
Species: All species
Last Modified: 2015-06-01
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.