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Monitor peptide gene expression is increased by exogenous CCK in the rat pancreas and in a rat pancreatic acinar cell line (AR4-2J).

Authors: Tsuzuki, S  Kondo, A  Fushiki, T  Sugimoto, E 
Citation: Tsuzuki S, etal., FEBS Lett. 1992 Aug 3;307(3):386-8.
Pubmed: (View Article at PubMed) PMID:1379547

Monitor peptide (CCK-releasing peptide) mRNA increased on the administration of CCK in rat pancreas and the AR4-2J pancreatic cell line. Subcutaneous injection of CCK into rats at 8 h intervals increased the level of monitor peptide mRNA in the pancreas. Concomitant injection of CCK antagonist CR-1409 strongly decreased it. The monitor peptide mRNA was also increased by CCK in AR4-2J cells and was decreased by the antagonist. These findings suggest that the plasma CCK induced by prolonged intake of a high protein diet may be responsible for the adaptative increase in the monitor peptide as well as exocrine proteases in the pancreas.

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CRRD Object Information
CRRD ID: 10044256
Created: 2015-06-05
Species: All species
Last Modified: 2015-06-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.