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Down-regulation of IGF-1/IGF-1R in hippocampus of rats with vascular dementia.

Authors: Gong, X  Ma, M  Fan, X  Li, M  Liu, Q  Liu, X  Xu, G 
Citation: Gong X, etal., Neurosci Lett. 2012 Mar 28;513(1):20-4. doi: 10.1016/j.neulet.2012.01.077. Epub 2012 Feb 10.
Pubmed: (View Article at PubMed) PMID:22342912
DOI: Full-text: DOI:10.1016/j.neulet.2012.01.077

Insulin-like growth factor-1 (IGF-1) has been demonstrated to have neuroprotective effects, but little is known concerning its role in vascular dementia (VaD). This study aimed to evaluate expression of IGF-1 signaling in hippocampus in rat model of VaD, and probe the underlying mechanisms. Permanent occlusion of bilateral common carotid arteries (2-VO) was used as VaD model. Learning and memory functions were declined significantly in 2-VO rats, and these impairments were further deteriorated with the prolongation of 2-VO treatment. IGF-1, IGF-1 receptor (IGF-1R), total Akt and phosphorylated Akt (p-Akt) were all measured at 1, 2 and 4 months following 2-VO injury. Compared with controls, IGF-1, IGF-1 mRNA and p-Akt expression were significantly decreased in hippocampus of 2-VO rats. However, changes of IGF-1R and total Akt levels were not significant. These results suggest that down-regulation of IGF-1 and p-Akt may contribute to the impairments of learning and memory functions after 2-VO. IGF-1/IGF-1R signaling system may involved in the onset and development of VaD.

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CRRD Object Information
CRRD ID: 10045864
Created: 2015-06-18
Species: All species
Last Modified: 2015-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.