Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

The genetic control of blood pressure and body composition in rats with stress-sensitive hypertension.

Authors: Redina, OE  Smolenskaya, SE  Maslova, LN  Markel, AL 
Citation: Redina OE, etal., Clin Exp Hypertens. 2013;35(7):484-95. doi: 10.3109/10641963.2012.758274. Epub 2013 Jan 9.
Pubmed: (View Article at PubMed) PMID:23302051
DOI: Full-text: DOI:10.3109/10641963.2012.758274

The genetic basis of the stress-sensitive arterial hypertension was investigated using the quantitative trait loci (QTL) approach. Two groups of F2 (inherited stress-induced arterial hypertension [ISIAH] x Wistar albino Glaxo [WAG]) hybrid males of different age (3-4 months old and 6 months old) were tested for blood pressure at rest and stressed conditions and for body composition traits. Several novel loci for the traits were determined. Some loci for blood pressure and organ weight were mapped to the same genetic region in rats of different age. The dynamic change of QTL effects in two rat groups of different age might reflect the process of stress-sensitive hypertension development.


Disease Annotations
Phenotype Annotations
Objects Annotated
Objects referenced in this article

Additional Information

CRRD Object Information
CRRD ID: 10053637
Created: 2015-07-16
Species: All species
Last Modified: 2015-07-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.